Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4324232..4324827 Replicon chromosome
Accession NZ_CP102379
Organism Escherichia coli strain BM28 lysU

Toxin (Protein)


Gene name chpB Uniprot ID U9XNP6
Locus tag NR350_RS20945 Protein ID WP_000239577.1
Coordinates 4324477..4324827 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag NR350_RS20940 Protein ID WP_001223208.1
Coordinates 4324232..4324483 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NR350_RS20930 (4319897) 4319897..4323676 + 3780 WP_262515045.1 autotransporter assembly complex protein TamB -
NR350_RS20935 (4323679) 4323679..4324020 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
NR350_RS20940 (4324232) 4324232..4324483 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
NR350_RS20945 (4324477) 4324477..4324827 + 351 WP_000239577.1 endoribonuclease toxin ChpB Toxin
NR350_RS20950 (4324907) 4324907..4325437 - 531 WP_000055075.1 inorganic diphosphatase -
NR350_RS20955 (4325747) 4325747..4326703 + 957 WP_000265913.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
NR350_RS20960 (4326843) 4326843..4328345 + 1503 WP_000205805.1 sugar ABC transporter ATP-binding protein -
NR350_RS20965 (4328359) 4328359..4329381 + 1023 WP_001313531.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12492.40 Da        Isoelectric Point: 5.5572

>T253556 WP_000239577.1 NZ_CP102379:4324477-4324827 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT253556 WP_001223208.1 NZ_CP102379:4324232-4324483 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References