Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | rnlAB/RnlA-RnlB |
| Location | 2635687..2637124 | Replicon | chromosome |
| Accession | NZ_CP102379 | ||
| Organism | Escherichia coli strain BM28 lysU | ||
Toxin (Protein)
| Gene name | rnlA | Uniprot ID | P52129 |
| Locus tag | NR350_RS12865 | Protein ID | WP_000155570.1 |
| Coordinates | 2635687..2636760 (+) | Length | 358 a.a. |
Antitoxin (Protein)
| Gene name | rnlB | Uniprot ID | P52130 |
| Locus tag | NR350_RS12870 | Protein ID | WP_000461704.1 |
| Coordinates | 2636753..2637124 (+) | Length | 124 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NR350_RS12850 (2631119) | 2631119..2633308 | - | 2190 | WP_000136402.1 | DEAD/DEAH box helicase | - |
| NR350_RS12855 (2633305) | 2633305..2634921 | - | 1617 | WP_000445380.1 | anti-bacteriophage protein AbpA | - |
| NR350_RS12860 (2635281) | 2635281..2635544 | - | 264 | WP_000502050.1 | DUF1524 domain-containing protein | - |
| NR350_RS12865 (2635687) | 2635687..2636760 | + | 1074 | WP_000155570.1 | type II toxin-antitoxin system toxin mRNA endoribonuclease RnlA | Toxin |
| NR350_RS12870 (2636753) | 2636753..2637124 | + | 372 | WP_000461704.1 | type II toxin-antitoxin system antitoxin RnlB | Antitoxin |
| NR350_RS12875 (2637479) | 2637479..2638342 | + | 864 | WP_000787597.1 | GTPase family protein | - |
| NR350_RS12880 (2638434) | 2638434..2639255 | + | 822 | WP_000197391.1 | DUF932 domain-containing protein | - |
| NR350_RS12885 (2639472) | 2639472..2640173 | + | 702 | WP_000189409.1 | WYL domain-containing protein | - |
| NR350_RS12890 (2640214) | 2640214..2640450 | + | 237 | WP_001144029.1 | protein YpjK | - |
| NR350_RS12895 (2640450) | 2640450..2640893 | + | 444 | WP_000824222.1 | lipoprotein YfjS | - |
| NR350_RS12900 (2640917) | 2640917..2641384 | + | 468 | WP_000702495.1 | protein YfjT | - |
| NR350_RS12905 (2641771) | 2641771..2641923 | - | 153 | Protein_2520 | arsenate reductase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 358 a.a. Molecular weight: 40061.13 Da Isoelectric Point: 6.8293
>T253548 WP_000155570.1 NZ_CP102379:2635687-2636760 [Escherichia coli]
MTIRSYKNLNLVRANIETESRQFIENKNYSIQSIGPMPGSRAGLRVVFTRPGVNLATVDIFYNGDGSTTIQYLTGANRSL
GQELADHLFETINPAEFEQVNMVLQGFVETSVLPVLELSADESHIEFREHSRNAHTVVWKIISTSYQDELTVSLHITTGK
LQIQGRPLSCYRVFTFNLAALLDLQGLEKVLIRQEDGKANIVQQEVARTYLQTVMADAYPHLHVTAEKLLVSGLCVKLAA
PDLPDYCMLLYPELRTIEGVLKSKMSGLGMPVQQPAGFGTYFDKPAAHYILKPQFAATLRPEQINIISTAYTFFNVERHS
LFHMETVVDASRMISDMARLMGKATRAWGIIKDLYIV
MTIRSYKNLNLVRANIETESRQFIENKNYSIQSIGPMPGSRAGLRVVFTRPGVNLATVDIFYNGDGSTTIQYLTGANRSL
GQELADHLFETINPAEFEQVNMVLQGFVETSVLPVLELSADESHIEFREHSRNAHTVVWKIISTSYQDELTVSLHITTGK
LQIQGRPLSCYRVFTFNLAALLDLQGLEKVLIRQEDGKANIVQQEVARTYLQTVMADAYPHLHVTAEKLLVSGLCVKLAA
PDLPDYCMLLYPELRTIEGVLKSKMSGLGMPVQQPAGFGTYFDKPAAHYILKPQFAATLRPEQINIISTAYTFFNVERHS
LFHMETVVDASRMISDMARLMGKATRAWGIIKDLYIV
Download Length: 1074 bp
Antitoxin
Download Length: 124 a.a. Molecular weight: 13664.69 Da Isoelectric Point: 4.2391
>AT253548 WP_000461704.1 NZ_CP102379:2636753-2637124 [Escherichia coli]
MFEITGINVSGALKAVVMATGFENPLSSVNEIETKLSALLGSETTGEILFDLLCANGPEWNRFVTLEMKYGRIMLDTAKI
IDEQDVPTHILSKLTFTLRNHPEYLEASVLSPDDVRQVLSMDF
MFEITGINVSGALKAVVMATGFENPLSSVNEIETKLSALLGSETTGEILFDLLCANGPEWNRFVTLEMKYGRIMLDTAKI
IDEQDVPTHILSKLTFTLRNHPEYLEASVLSPDDVRQVLSMDF
Download Length: 372 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|