Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1381725..1382363 Replicon chromosome
Accession NZ_CP102379
Organism Escherichia coli strain BM28 lysU

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag NR350_RS06740 Protein ID WP_000813794.1
Coordinates 1381725..1381901 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NR350_RS06745 Protein ID WP_001270286.1
Coordinates 1381947..1382363 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NR350_RS06720 (1377345) 1377345..1378519 - 1175 Protein_1308 BenE family transporter YdcO -
NR350_RS06725 (1378611) 1378611..1379147 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
NR350_RS06730 (1379220) 1379220..1381181 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
NR350_RS06735 (1381273) 1381273..1381503 - 231 WP_000494244.1 YncJ family protein -
NR350_RS06740 (1381725) 1381725..1381901 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
NR350_RS06745 (1381947) 1381947..1382363 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
NR350_RS06750 (1382442) 1382442..1383848 + 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
NR350_RS06755 (1384093) 1384093..1385238 + 1146 WP_000047424.1 ABC transporter substrate-binding protein -
NR350_RS06760 (1385256) 1385256..1386269 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
NR350_RS06765 (1386270) 1386270..1387211 + 942 WP_001251304.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T253539 WP_000813794.1 NZ_CP102379:1381725-1381901 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT253539 WP_001270286.1 NZ_CP102379:1381947-1382363 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References