Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 366273..366891 Replicon chromosome
Accession NZ_CP102379
Organism Escherichia coli strain BM28 lysU

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NR350_RS01760 Protein ID WP_001291435.1
Coordinates 366273..366491 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NR350_RS01765 Protein ID WP_000344800.1
Coordinates 366517..366891 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NR350_RS01725 (361562) 361562..362134 + 573 WP_000779842.1 YbaY family lipoprotein -
NR350_RS01730 (362165) 362165..362476 - 312 WP_000409911.1 MGMT family protein -
NR350_RS01740 (362855) 362855..363208 + 354 WP_000878140.1 DUF1428 domain-containing protein -
NR350_RS01745 (363250) 363250..364800 - 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NR350_RS01750 (364964) 364964..365434 - 471 WP_000136192.1 YlaC family protein -
NR350_RS01755 (365550) 365550..366101 - 552 WP_000102564.1 maltose O-acetyltransferase -
NR350_RS01760 (366273) 366273..366491 - 219 WP_001291435.1 HHA domain-containing protein Toxin
NR350_RS01765 (366517) 366517..366891 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NR350_RS01770 (367437) 367437..370586 - 3150 WP_262515548.1 efflux RND transporter permease AcrB -
NR350_RS01775 (370609) 370609..371802 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T253529 WP_001291435.1 NZ_CP102379:c366491-366273 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT253529 WP_000344800.1 NZ_CP102379:c366891-366517 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References