Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3051052..3051706 Replicon chromosome
Accession NZ_CP102378
Organism Escherichia coli strain JB41

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag NR351_RS14925 Protein ID WP_000244777.1
Coordinates 3051052..3051459 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag NR351_RS14930 Protein ID WP_000354046.1
Coordinates 3051440..3051706 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NR351_RS14905 (3047009) 3047009..3048742 - 1734 WP_000813200.1 single-stranded-DNA-specific exonuclease RecJ -
NR351_RS14910 (3048748) 3048748..3049458 - 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NR351_RS14915 (3049483) 3049483..3050379 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
NR351_RS14920 (3050491) 3050491..3051012 + 522 WP_001055874.1 flavodoxin FldB -
NR351_RS14925 (3051052) 3051052..3051459 - 408 WP_000244777.1 protein YgfX Toxin
NR351_RS14930 (3051440) 3051440..3051706 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
NR351_RS14935 (3051949) 3051949..3052929 + 981 WP_000886062.1 tRNA-modifying protein YgfZ -
NR351_RS14940 (3053125) 3053125..3053784 - 660 WP_000250274.1 hemolysin III family protein -
NR351_RS14945 (3053948) 3053948..3054259 - 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
NR351_RS14950 (3054304) 3054304..3055737 + 1434 WP_001336277.1 6-phospho-beta-glucosidase BglA -
NR351_RS14955 (3055794) 3055794..3056537 - 744 WP_000951964.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T253516 WP_000244777.1 NZ_CP102378:c3051459-3051052 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT253516 WP_000354046.1 NZ_CP102378:c3051706-3051440 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References