253514

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 2787751..2788418 Replicon chromosome
Accession NZ_CP102378
Organism Escherichia coli strain JB41

Toxin (Protein)


Gene name ypjF Uniprot ID Q46953
Locus tag NR351_RS13710 Protein ID WP_001094400.1
Coordinates 2788089..2788418 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID P52141
Locus tag NR351_RS13705 Protein ID WP_000072690.1
Coordinates 2787751..2788068 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NR351_RS13675 (2782803) 2782803..2783812 - 1010 Protein_2673 arsenic transporter -
NR351_RS13680 (2783954) 2783954..2785657 + 1704 WP_000896263.1 protein YfjW -
NR351_RS13685 (2786229) 2786229..2786452 + 224 Protein_2675 DUF905 domain-containing protein -
NR351_RS13690 (2786555) 2786555..2787013 + 459 WP_000211841.1 antirestriction protein -
NR351_RS13695 (2787022) 2787022..2787504 + 483 WP_001407480.1 RadC family protein -
NR351_RS13700 (2787513) 2787513..2787713 + 201 WP_001395452.1 DUF987 domain-containing protein -
NR351_RS13705 (2787751) 2787751..2788068 + 318 WP_000072690.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NR351_RS13710 (2788089) 2788089..2788418 + 330 WP_001094400.1 type IV toxin-antitoxin system toxin YpjF Toxin
NR351_RS13715 (2788782) 2788782..2793362 - 4581 WP_010723187.1 adhesin-like autotransporter YpjA/EhaD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12308.21 Da        Isoelectric Point: 7.2761

>T253514 WP_001094400.1 NZ_CP102378:2788089-2788418 [Escherichia coli]
MNTLPATISQAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVEKYELVRIDHRGF
SWQQQSPYISVVDILRARRSTGLLKTNVK

Download         Length: 330 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11737.27 Da        Isoelectric Point: 6.4630

>AT253514 WP_000072690.1 NZ_CP102378:2787751-2788068 [Escherichia coli]
MSNTTWGLQRDITPRLGARLVQEGNQLHYLADRASITGKFSDAECPKLDVVFPHFISQIESMLTTGELNPRHAQCVTLYH
NGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A373F4I3

Antitoxin

Source ID Structure
AlphaFold DB P52141

References