253506

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1655982..1656508 Replicon chromosome
Accession NZ_CP102378
Organism Escherichia coli strain JB41

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag NR351_RS08185 Protein ID WP_000323025.1
Coordinates 1655982..1656269 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag NR351_RS08190 Protein ID WP_000534858.1
Coordinates 1656269..1656508 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NR351_RS08135 (1651006) 1651006..1651221 - 216 WP_000839590.1 phage lysis protein EssD -
NR351_RS08140 (1651441) 1651441..1651611 + 171 WP_211180497.1 putative zinc-binding protein YnfU -
NR351_RS08145 (1651975) 1651975..1652190 - 216 WP_000066484.1 cold shock-like protein CspB -
NR351_RS08150 (1652491) 1652491..1652703 + 213 WP_000087756.1 cold shock-like protein CspF -
NR351_RS08155 (1652758) 1652758..1652847 + 90 WP_120795389.1 hypothetical protein -
NR351_RS08160 (1653125) 1653125..1653877 - 753 WP_001047135.1 antitermination protein -
NR351_RS08165 (1653891) 1653891..1654940 - 1050 WP_001393597.1 DUF968 domain-containing protein -
NR351_RS08170 (1654942) 1654942..1655220 - 279 WP_012304870.1 hypothetical protein -
NR351_RS08175 (1655287) 1655287..1655538 - 252 WP_000980994.1 protein Rem -
NR351_RS08180 (1655755) 1655755..1655910 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
NR351_RS08185 (1655982) 1655982..1656269 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
NR351_RS08190 (1656269) 1656269..1656508 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
NR351_RS08195 (1656533) 1656533..1656838 + 306 WP_001326990.1 protein YdfV -
NR351_RS08200 (1657041) 1657041..1657373 + 333 WP_001301033.1 FlxA-like family protein -
NR351_RS08205 (1657810) 1657810..1657959 - 150 WP_011443592.1 protein YdfW -
NR351_RS08210 (1657994) 1657994..1658272 - 279 Protein_1605 hypothetical protein -
NR351_RS08215 (1658256) 1658256..1658486 - 231 WP_000920568.1 dicB transcriptional regulator DicC -
NR351_RS08220 (1658570) 1658570..1658977 + 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
NR351_RS08225 (1659144) 1659144..1659299 + 156 WP_000379575.1 DUF1391 family protein -
NR351_RS08230 (1659301) 1659301..1659429 + 129 WP_000344964.1 protein YdfB -
NR351_RS08235 (1659459) 1659459..1659677 + 219 WP_001171942.1 protein YdfC -
NR351_RS08240 (1660245) 1660245..1660433 + 189 WP_000854559.1 cell division inhibition protein DicB -
NR351_RS08245 (1660430) 1660430..1660621 + 192 WP_001083297.1 lysis protein YdfD -
NR351_RS08250 (1660714) 1660714..1661481 + 768 Protein_1613 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1634741..1667380 32639


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T253506 WP_000323025.1 NZ_CP102378:c1656269-1655982 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT253506 WP_000534858.1 NZ_CP102378:c1656508-1656269 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References