Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1519922..1520560 Replicon chromosome
Accession NZ_CP102378
Organism Escherichia coli strain JB41

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag NR351_RS07505 Protein ID WP_000813794.1
Coordinates 1519922..1520098 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NR351_RS07510 Protein ID WP_001270286.1
Coordinates 1520144..1520560 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NR351_RS07485 (1515541) 1515541..1516755 - 1215 WP_001326689.1 BenE family transporter YdcO -
NR351_RS07490 (1516808) 1516808..1517344 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
NR351_RS07495 (1517417) 1517417..1519378 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
NR351_RS07500 (1519470) 1519470..1519700 - 231 WP_000494244.1 YncJ family protein -
NR351_RS07505 (1519922) 1519922..1520098 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
NR351_RS07510 (1520144) 1520144..1520560 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
NR351_RS07515 (1520639) 1520639..1522045 + 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
NR351_RS07520 (1522290) 1522290..1523435 + 1146 WP_000047424.1 ABC transporter substrate-binding protein -
NR351_RS07525 (1523453) 1523453..1524466 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
NR351_RS07530 (1524467) 1524467..1525408 + 942 WP_001251304.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T253504 WP_000813794.1 NZ_CP102378:1519922-1520098 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT253504 WP_001270286.1 NZ_CP102378:1520144-1520560 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References