Detailed information of TA system TA025350

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 387328..389050
• Replicon: chromosome
• Accession: NC_015633
• Organism: Vibrio anguillarum 775

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: F7YIZ5
• Locus tag: VAA_RS01800
• Protein ID: WP_013855709.1
• Coordinates: 388112..389050 (+)
• Length: 313 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: VAA_RS01795
• Protein ID: WP_013855708.1
• Coordinates: 387328..388119 (+)
• Length: 264 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
VAA_RS01780	384858..385082	-	225	WP_001147121.1	hypothetical protein	-
VAA_RS01785	385083..385367	-	285	WP_013855706.1	helix-turn-helix domain-containing protein	-
VAA_RS01790	385364..387058	-	1695	WP_013855707.1	DUF927 domain-containing protein	-
VAA_RS01795	387328..388119	+	792	WP_013855708.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
VAA_RS01800	388112..389050	+	939	WP_013855709.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
VAA_RS01805	389089..391236	+	2148	WP_013855710.1	site-specific DNA-methyltransferase	-
VAA_RS01810	391239..393839	+	2601	WP_013855711.1	DEAD/DEAH box helicase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (13-278)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (99-250)

Sequences

Toxin

Protein

• Length: 313 a.a.
• Molecular weight: 35361.46 Da
• Isoelectric Point: 4.7638

>T25350 WP_013855709.1 NC_015633:388112-389050 [Vibrio anguillarum 775]
MDRESPYYKQVSLLIRMLPVVATEPSFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRNEALANVKAALQRITDLINKE
PENRAVLQDHRLDELRIVVTSPNATIKIEVSPVARGTLHKPDSLAVQESVEEEFGYAEIPVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLAEEGISRDIFVGFITYVLSHPRPINEVMAPNWQPLDDKFQAEFDGMTFEPVELNDLISTRPAMVAALQA
HFTEKDRSFLLSFKQGNPDWSLFDYPDAAELPAIRWKLQNIAKLAKNQEKHVEQLTKLESVLDDWLKQANSN

Nucleotide

• Length: 939 bp

>T25350 NC_015633:388112-389050 [Vibrio anguillarum 775]
ATGGATAGAGAGAGCCCTTATTACAAGCAGGTTTCACTGCTGATTAGAATGTTACCAGTGGTTGCAACAGAACCTTCATT
TGCACTTAAAGGTGGTACAGCTATCAACTTATTTGTGAGGGATTTTCCACGCTTGTCTGTGGATATTGATCTTGCTTATC
TTCCTCTTGAGCCCCGAAATGAAGCTCTAGCAAATGTAAAAGCAGCATTGCAACGTATAACCGATTTAATCAACAAAGAA
CCTGAGAACCGAGCTGTATTGCAGGACCATAGGTTAGATGAATTGCGTATTGTTGTTACAAGTCCTAATGCAACAATTAA
AATAGAAGTCTCTCCGGTAGCAAGAGGTACGTTGCATAAACCTGATAGCTTAGCTGTCCAAGAATCAGTCGAAGAAGAGT
TTGGTTATGCAGAGATTCCTGTAGTTAGTCTGCCCGATCTTTATGGCGGAAAACTATGTGCTGCCATGGATCGCCAGCAC
CCTCGCGACCTGTTTGATGTTCGTATGCTGCTTGCAGAAGAAGGTATTTCACGAGATATCTTTGTTGGATTCATTACTTA
CGTACTAAGCCACCCAAGACCTATCAATGAGGTTATGGCTCCTAACTGGCAACCTCTTGATGATAAGTTTCAAGCTGAGT
TCGATGGCATGACCTTTGAACCCGTTGAGTTAAACGACTTAATTTCTACAAGGCCTGCGATGGTAGCTGCACTACAAGCC
CATTTCACAGAAAAAGATCGCTCATTTTTGTTGTCATTCAAACAAGGTAATCCTGATTGGTCACTGTTTGACTACCCAGA
TGCAGCAGAACTGCCAGCTATACGCTGGAAGCTACAAAACATAGCTAAGTTAGCTAAAAATCAAGAAAAACATGTAGAGC
AGCTAACTAAATTAGAGTCTGTACTTGATGATTGGCTTAAGCAAGCCAACTCCAATTAA

Antitoxin

Protein

• Length: 264 a.a.
• Molecular weight: 29934.05 Da
• Isoelectric Point: 9.6742

>AT25350 WP_013855708.1 NC_015633:387328-388119 [Vibrio anguillarum 775]
MSSKINWLVANAYPGALVLQQWLTENGISYSLAQKYAQSGWLRKLSSGVYYRPSARDDVKPGWVDALQAMDTQLHHRVHL
AGLSSLTHQGLSHYLQLSKEQVWIGVKNKQSLPKWFREFPNQNWFYCGNHKLEAVSDKDLKVITVKGKELKASCPELAAY
EVVDAIGKQISFEHAAELFQGLVNLSPRKVQSLLERSSSVQTNRVFLFLSHYHGHQWTQRIDETKIALGSGKRQVVEQGR
FDERYQITVPEILSVKKEEANNG

Nucleotide

• Length: 792 bp

>AT25350 NC_015633:387328-388119 [Vibrio anguillarum 775]
ATGTCATCCAAGATAAACTGGTTGGTAGCCAATGCATATCCTGGAGCCCTTGTGCTACAGCAATGGCTGACTGAGAACGG
AATTAGCTATTCCTTAGCTCAAAAATATGCGCAGAGTGGTTGGCTTAGGAAGCTATCTTCTGGCGTTTATTATCGGCCAA
GCGCAAGAGATGATGTTAAGCCGGGCTGGGTGGATGCTCTACAAGCGATGGACACACAGTTGCACCATCGTGTTCATCTG
GCTGGGTTAAGCAGCTTAACTCACCAAGGGCTGAGCCACTATTTACAGCTAAGTAAAGAACAAGTTTGGATAGGGGTGAA
GAACAAACAATCATTGCCTAAGTGGTTTCGTGAATTTCCCAATCAAAATTGGTTTTATTGTGGTAACCATAAGCTTGAAG
CTGTCTCTGACAAGGACCTAAAAGTGATTACGGTTAAAGGAAAAGAGCTAAAAGCTAGTTGCCCAGAGCTTGCTGCTTAC
GAAGTTGTTGATGCAATCGGGAAGCAAATTTCTTTTGAGCATGCAGCAGAGCTTTTTCAAGGCCTCGTAAACCTGAGTCC
TAGAAAGGTGCAATCTCTTCTTGAACGTAGTAGCTCGGTTCAAACCAATAGAGTGTTTTTGTTCTTGAGTCATTATCATG
GGCATCAGTGGACTCAGCGCATTGATGAAACAAAGATCGCATTAGGTTCAGGAAAGCGTCAGGTGGTAGAGCAAGGGCGA
TTTGATGAGCGTTACCAAATCACTGTGCCAGAAATATTAAGTGTAAAAAAAGAAGAAGCAAACAATGGATAG

Structures

Toxin

• AlphaFold DB: F7YIZ5