Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 489467..490085 Replicon chromosome
Accession NZ_CP102378
Organism Escherichia coli strain JB41

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NR351_RS02425 Protein ID WP_001291435.1
Coordinates 489467..489685 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NR351_RS02430 Protein ID WP_000344800.1
Coordinates 489711..490085 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NR351_RS02390 (484756) 484756..485328 + 573 WP_000779842.1 YbaY family lipoprotein -
NR351_RS02395 (485359) 485359..485670 - 312 WP_000409911.1 MGMT family protein -
NR351_RS02405 (486049) 486049..486402 + 354 WP_000878140.1 DUF1428 domain-containing protein -
NR351_RS02410 (486444) 486444..487994 - 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NR351_RS02415 (488158) 488158..488628 - 471 WP_000136192.1 YlaC family protein -
NR351_RS02420 (488744) 488744..489295 - 552 WP_000102564.1 maltose O-acetyltransferase -
NR351_RS02425 (489467) 489467..489685 - 219 WP_001291435.1 HHA domain-containing protein Toxin
NR351_RS02430 (489711) 489711..490085 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NR351_RS02435 (490631) 490631..493780 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
NR351_RS02440 (493803) 493803..494996 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T253494 WP_001291435.1 NZ_CP102378:c489685-489467 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT253494 WP_000344800.1 NZ_CP102378:c490085-489711 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References