Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 2750799..2751327 Replicon chromosome
Accession NZ_CP102374
Organism Pseudomonas sp. T8

Toxin (Protein)


Gene name relE Uniprot ID A0A7S5LMJ4
Locus tag NRG23_RS12255 Protein ID WP_038581545.1
Coordinates 2751028..2751327 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7S5HLJ1
Locus tag NRG23_RS12250 Protein ID WP_038581543.1
Coordinates 2750799..2751038 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NRG23_RS12220 (NRG23_12220) 2746063..2746218 - 156 Protein_2422 restriction endonuclease -
NRG23_RS12225 (NRG23_12225) 2746381..2747271 + 891 WP_257374667.1 phosphotransferase -
NRG23_RS12230 (NRG23_12230) 2747365..2747889 - 525 WP_009047451.1 DUF4142 domain-containing protein -
NRG23_RS12235 (NRG23_12235) 2748028..2749368 - 1341 WP_009047450.1 sensor domain-containing diguanylate cyclase -
NRG23_RS12240 (NRG23_12240) 2749480..2750118 - 639 WP_016702101.1 LysE family translocator -
NRG23_RS12245 (NRG23_12245) 2750246..2750662 - 417 WP_009047448.1 fosfomycin resistance glutathione transferase -
NRG23_RS12250 (NRG23_12250) 2750799..2751038 + 240 WP_038581543.1 ribbon-helix-helix protein, CopG family Antitoxin
NRG23_RS12255 (NRG23_12255) 2751028..2751327 + 300 WP_038581545.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NRG23_RS12260 (NRG23_12260) 2751387..2752535 - 1149 WP_110177469.1 L-threonine dehydrogenase -
NRG23_RS12265 (NRG23_12265) 2752693..2753712 + 1020 WP_009047445.1 DUF4917 family protein -
NRG23_RS12270 (NRG23_12270) 2753931..2754473 - 543 WP_007922237.1 XRE family transcriptional regulator -
NRG23_RS12275 (NRG23_12275) 2754633..2755415 + 783 WP_041988770.1 aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-82)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-41)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11487.13 Da        Isoelectric Point: 10.8916

>T253484 WP_038581545.1 NZ_CP102374:2751028-2751327 [Pseudomonas sp. T8]
MHVEWLRSALKNLDDEAAYIAQDSPQAAAEFVKAILSSIQHLSRFPASGREGRLPGTREWVVPNRPYLIPYRVRQGRLQI
LRIFHTRRLPPAGWQDDRQ

Download         Length: 300 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8648.73 Da        Isoelectric Point: 4.5535

>AT253484 WP_038581543.1 NZ_CP102374:2750799-2751038 [Pseudomonas sp. T8]
MSVMSLRLPDDVADTLAHLAKATGRSKSFLAVDALREYLAREAWQINEIQKALTEAEAGDFASAEELDGVLNKWTGNAR

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7S5LMJ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7S5HLJ1

References