Detailed information of TA system TA253480

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 5225765..5226290
• Replicon: chromosome
• Accession: NZ_CP102359
• Organism: Streptomyces sp. B146

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: M6G09_RS23180
• Protein ID: WP_224335784.1
• Coordinates: 5225765..5226028 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: M6G09_RS23185
• Protein ID: WP_194276153.1
• Coordinates: 5226021..5226290 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M6G09_RS23160 (M6G09_23210)	5221943..5222968	+	1026	WP_195888464.1	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-
M6G09_RS23165 (M6G09_23215)	5223047..5223787	+	741	WP_194276159.1	ROK family protein	-
M6G09_RS23170 (M6G09_23220)	5223798..5224391	-	594	WP_224292487.1	hypothetical protein	-
M6G09_RS23175 (M6G09_23225)	5224552..5225640	+	1089	WP_194276157.1	redox-regulated ATPase YchF	-
M6G09_RS23180 (M6G09_23230)	5225765..5226028	-	264	WP_224335784.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
M6G09_RS23185 (M6G09_23235)	5226021..5226290	-	270	WP_194276153.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
M6G09_RS23190 (M6G09_23240)	5226627..5227568	+	942	WP_277724684.1	helix-turn-helix transcriptional regulator	-
M6G09_RS23195 (M6G09_23245)	5227634..5228548	+	915	WP_224335781.1	MBL fold metallo-hydrolase	-
M6G09_RS23200 (M6G09_23250)	5228571..5230133	+	1563	WP_277724683.1	carboxylesterase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-58)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10087.58 Da
• Isoelectric Point: 9.4306

>T253480 WP_224335784.1 NZ_CP102359:c5226028-5225765 [Streptomyces sp. B146]
VSEYRTVFRPEAQAELRKIPRDMALRILTKLTELESDPLGYSTTALVSQPERRRLRVGDYRVVYTIDKGELVVWVVHVGH
RSTVYEA

Nucleotide

• Length: 264 bp

>T253480 NZ_CP102359:c5226028-5225765 [Streptomyces sp. B146]
GTGAGTGAATACCGAACCGTCTTCCGGCCAGAGGCACAGGCCGAGCTCCGGAAGATCCCTCGCGACATGGCCCTACGCAT
CCTGACCAAACTGACCGAACTGGAGAGCGACCCCCTCGGCTATAGCACCACCGCGCTCGTGTCCCAGCCAGAACGCCGTC
GACTGCGGGTCGGCGACTACCGGGTCGTCTACACGATCGACAAGGGGGAGCTCGTGGTGTGGGTCGTCCACGTCGGGCAT
CGCTCCACCGTTTACGAAGCCTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10286.78 Da
• Isoelectric Point: 4.7574

>AT253480 WP_194276153.1 NZ_CP102359:c5226290-5226021 [Streptomyces sp. B146]
MTQPLPIESIRDVRAHLAEVVERADRDDVPTVITRRGKQIAAVVSIEVLRKYQEWEEREINRIIDERMANPAPGIPIEEI
MRETLARGE

Nucleotide

• Length: 270 bp

>AT253480 NZ_CP102359:c5226290-5226021 [Streptomyces sp. B146]
ATGACGCAGCCACTGCCCATAGAGTCCATCCGCGACGTACGTGCGCACCTGGCCGAGGTCGTGGAGCGCGCCGATCGGGA
TGATGTGCCCACCGTGATCACTCGACGGGGCAAGCAGATTGCCGCCGTCGTCTCCATCGAGGTGCTGCGCAAGTACCAGG
AATGGGAAGAGCGCGAGATCAATCGGATCATCGACGAACGCATGGCCAACCCGGCACCCGGCATCCCGATCGAGGAGATC
ATGAGGGAGACGCTGGCACGCGGTGAGTGA