Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 4215583..4216211 Replicon chromosome
Accession NZ_CP102359
Organism Streptomyces sp. B146

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag M6G09_RS18445 Protein ID WP_243780232.1
Coordinates 4215801..4216211 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag M6G09_RS18440 Protein ID WP_031046014.1
Coordinates 4215583..4215804 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M6G09_RS18415 (M6G09_18455) 4210933..4211148 - 216 WP_224299939.1 hypothetical protein -
M6G09_RS18420 (M6G09_18460) 4211664..4212473 + 810 WP_277725443.1 peptidoglycan-binding protein -
M6G09_RS18425 (M6G09_18465) 4212470..4213366 + 897 WP_277725444.1 XRE family transcriptional regulator -
M6G09_RS18430 (M6G09_18470) 4213413..4214552 - 1140 WP_277725445.1 NAD(P)/FAD-dependent oxidoreductase -
M6G09_RS18435 (M6G09_18475) 4214715..4215407 - 693 WP_194276764.1 TetR/AcrR family transcriptional regulator C-terminal domain-containing protein -
M6G09_RS18440 (M6G09_18480) 4215583..4215804 + 222 WP_031046014.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
M6G09_RS18445 (M6G09_18485) 4215801..4216211 + 411 WP_243780232.1 PIN domain-containing protein Toxin
M6G09_RS18455 (M6G09_18495) 4217156..4217731 + 576 WP_031043809.1 dCTP deaminase -
M6G09_RS18460 (M6G09_18500) 4217757..4218266 + 510 WP_277725446.1 phosphoribosyltransferase -
M6G09_RS18465 (M6G09_18505) 4218425..4218556 + 132 WP_263446916.1 hypothetical protein -
M6G09_RS18470 (M6G09_18510) 4219001..4219123 - 123 Protein_3631 NUDIX hydrolase -
M6G09_RS18475 (M6G09_18515) 4219121..4219711 + 591 Protein_3632 replication initiation protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-42)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14957.58 Da        Isoelectric Point: 5.4153

>T253479 WP_243780232.1 NZ_CP102359:4215801-4216211 [Streptomyces sp. B146]
VMYLLDTSGLVRLLRDANLQSAWHDAIDAGAIASCYVQRTEFLYSARNRSEYDEIAEMFSDLYPDAAVPKNAGRWISAVQ
HRMAQAGEHRSASAVDLVIAATAAHHGLTVLHDDADYGTVARHASDLNEHNVHEVV

Download         Length: 411 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8585.65 Da        Isoelectric Point: 7.4050

>AT253479 WP_031046014.1 NZ_CP102359:4215583-4215804 [Streptomyces sp. B146]
MSVTQIDIDDDALERAMALAHVRTKKEAVNLALHFYAEQQERAARISRHFERAREWGAVEDAERLHRVEKRSR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References