Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 503007..503650 Replicon chromosome
Accession NZ_CP102358
Organism Pseudomonas zeae strain BIM B-582

Toxin (Protein)


Gene name hicA Uniprot ID A0A4R7VCK5
Locus tag NQ186_RS02200 Protein ID WP_026000492.1
Coordinates 503007..503189 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NQ186_RS02205 Protein ID WP_257356775.1
Coordinates 503249..503650 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQ186_RS02185 (NQ186_02185) 499016..499942 + 927 WP_016983653.1 serine acetyltransferase -
NQ186_RS02190 (NQ186_02190) 500394..502355 + 1962 WP_163030199.1 choline transporter BetT -
NQ186_RS02195 (NQ186_02195) 502381..502641 - 261 WP_007949845.1 hypothetical protein -
NQ186_RS02200 (NQ186_02200) 503007..503189 + 183 WP_026000492.1 type II toxin-antitoxin system HicA family toxin Toxin
NQ186_RS02205 (NQ186_02205) 503249..503650 + 402 WP_257356775.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NQ186_RS02210 (NQ186_02210) 503656..504693 - 1038 WP_257356777.1 LacI family DNA-binding transcriptional regulator -
NQ186_RS02215 (NQ186_02215) 504899..507124 + 2226 WP_257356778.1 TonB-dependent receptor -
NQ186_RS02220 (NQ186_02220) 507126..508445 + 1320 WP_257356779.1 LLM class flavin-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6903.02 Da        Isoelectric Point: 10.5417

>T253471 WP_026000492.1 NZ_CP102358:503007-503189 [Pseudomonas zeae]
MRSREMIRMIEDDGWYLVAVKGSHHQYKHPHKPGRVTIKHPDSDLPKGTINSILKQAGLK

Download         Length: 183 bp

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14723.53 Da        Isoelectric Point: 4.4631

>AT253471 WP_257356775.1 NZ_CP102358:503249-503650 [Pseudomonas zeae]
MKFPVVLHKDVDSDYGVIIPDVPGCFSAGTTVAEAFENTQEALALHYEGLVADNAPLPQVRDIDAHLDNPDYAGGIWGVV
DFDITPYFGKSVRFNATLPEQLLERIDQTVRRDQRYRSRSGFLAAAALRELSV

Download         Length: 402 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4R7VCK5

Antitoxin

Source ID Structure

References