Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1408688..1409316 Replicon chromosome
Accession NZ_CP102355
Organism Paracoccus sp. SMMA_5_TC

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag GB880_RS07135 Protein ID WP_154492180.1
Coordinates 1409128..1409316 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name hicA Uniprot ID -
Locus tag GB880_RS07130 Protein ID WP_154492182.1
Coordinates 1408688..1409083 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GB880_RS07105 (GB880_007105) 1404127..1404375 + 249 WP_154492192.1 phage tail assembly protein -
GB880_RS07110 (GB880_007110) 1404493..1406967 + 2475 WP_263467001.1 phage tail tape measure protein -
GB880_RS07115 (GB880_007115) 1406967..1407383 + 417 WP_154492188.1 phage tail protein -
GB880_RS07120 (GB880_007120) 1407346..1407567 + 222 WP_154492186.1 tail protein X -
GB880_RS07125 (GB880_007125) 1407597..1408583 + 987 WP_154492184.1 contractile injection system protein, VgrG/Pvc8 family -
GB880_RS07130 (GB880_007130) 1408688..1409083 - 396 WP_154492182.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GB880_RS07135 (GB880_007135) 1409128..1409316 - 189 WP_154492180.1 type II toxin-antitoxin system HicA family toxin Toxin
GB880_RS07140 (GB880_007140) 1409940..1410146 - 207 WP_154492177.1 hypothetical protein -
GB880_RS07145 (GB880_007145) 1410309..1411565 + 1257 WP_154492174.1 aspartate kinase -
GB880_RS07150 (GB880_007150) 1411597..1413846 + 2250 WP_154492171.1 phosphoenolpyruvate--protein phosphotransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(8-61)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-124)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7019.24 Da        Isoelectric Point: 11.3427

>T253470 WP_154492180.1 NZ_CP102355:c1409316-1409128 [Paracoccus sp. SMMA_5_TC]
MQIERNSRQILQVLKAAGFEEVSKRGSHLKLRKGERTVIVPHPKKDLPLGTARNIYQQAGLL

Download         Length: 189 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14013.90 Da        Isoelectric Point: 4.5486

>AT253470 WP_154492182.1 NZ_CP102355:c1409083-1408688 [Paracoccus sp. SMMA_5_TC]
MKQYSAIIHHDPGAAFGLTFPDLPGCFAAADCWDDVPKAASEALNLWFEDQPEVPPSPLDALLKRQDVAQALAEGATLIT
IPYIPADGTLERVNISIERGLLRAVDAAAKERGMTRSSFLASAARHELTGA

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References