Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1408817..1409445 Replicon chromosome
Accession NZ_CP102352
Organism Paracoccus sp. SMMA_5

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag GB879_RS07145 Protein ID WP_154492180.1
Coordinates 1409257..1409445 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name hicA Uniprot ID -
Locus tag GB879_RS07140 Protein ID WP_263475362.1
Coordinates 1408817..1409260 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GB879_RS07115 (GB879_007115) 1404256..1404504 + 249 WP_154492192.1 phage tail assembly protein -
GB879_RS07120 (GB879_007120) 1404622..1407096 + 2475 WP_263467001.1 phage tail tape measure protein -
GB879_RS07125 (GB879_007125) 1407096..1407512 + 417 WP_154492188.1 phage tail protein -
GB879_RS07130 (GB879_007130) 1407475..1407696 + 222 WP_154492186.1 tail protein X -
GB879_RS07135 (GB879_007135) 1407687..1408712 + 1026 WP_195841233.1 contractile injection system protein, VgrG/Pvc8 family -
GB879_RS07140 (GB879_007140) 1408817..1409260 - 444 WP_263475362.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GB879_RS07145 (GB879_007145) 1409257..1409445 - 189 WP_154492180.1 type II toxin-antitoxin system HicA family toxin Toxin
GB879_RS07150 (GB879_007150) 1410069..1410275 - 207 WP_154492177.1 hypothetical protein -
GB879_RS07155 (GB879_007155) 1410438..1411694 + 1257 WP_154492174.1 aspartate kinase -
GB879_RS07160 (GB879_007160) 1411726..1413975 + 2250 WP_154492171.1 phosphoenolpyruvate--protein phosphotransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(8-61)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(20-140)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7019.24 Da        Isoelectric Point: 11.3427

>T253468 WP_154492180.1 NZ_CP102352:c1409445-1409257 [Paracoccus sp. SMMA_5]
MQIERNSRQILQVLKAAGFEEVSKRGSHLKLRKGERTVIVPHPKKDLPLGTARNIYQQAGLL

Download         Length: 189 bp

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 15630.73 Da        Isoelectric Point: 4.4915

>AT253468 WP_263475362.1 NZ_CP102352:c1409260-1408817 [Paracoccus sp. SMMA_5]
VSPAHLILATNAEGELMKQYSAIIHHDPGAAFGLTFPDLPGCFAAADCWDDVPKAASEALNLWFEDQPEVPPSPLDALLK
RQDVAQALAEGATLITIPYIPADGTLERVNISIERGLLRAVDAAAKERGMTRSSFLASAARHELTGA

Download         Length: 444 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References