Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 5733783..5734424 Replicon chromosome
Accession NZ_CP102347
Organism Mycolicibacterium smegmatis strain LM14

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag NQ427_RS27295 Protein ID WP_011730672.1
Coordinates 5733783..5734226 (-) Length 148 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID I7FKW8
Locus tag NQ427_RS27300 Protein ID WP_011730673.1
Coordinates 5734236..5734424 (-) Length 63 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQ427_RS27275 (NQ427_27275) 5729266..5730003 + 738 WP_011730668.1 GntR family transcriptional regulator -
NQ427_RS27280 (NQ427_27280) 5730005..5731537 + 1533 WP_011730669.1 cyclohexanecarboxylate-CoA ligase -
NQ427_RS27285 (NQ427_27285) 5731538..5732311 + 774 WP_011730670.1 SDR family oxidoreductase -
NQ427_RS27290 (NQ427_27290) 5732308..5733780 + 1473 WP_011730671.1 long-chain fatty acid--CoA ligase -
NQ427_RS27295 (NQ427_27295) 5733783..5734226 - 444 WP_011730672.1 SRPBCC family protein Toxin
NQ427_RS27300 (NQ427_27300) 5734236..5734424 - 189 WP_011730673.1 antitoxin Antitoxin
NQ427_RS27305 (NQ427_27305) 5734450..5736825 - 2376 WP_011730674.1 cation-translocating P-type ATPase -
NQ427_RS27310 (NQ427_27310) 5736839..5738446 - 1608 WP_162139558.1 serine hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-141)

Antitoxin

Antitoxin Rv0909/MT0933

(4-52)


Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 16157.75 Da        Isoelectric Point: 9.9432

>T253464 WP_011730672.1 NZ_CP102347:c5734226-5733783 [Mycolicibacterium smegmatis]
MAKLSVSVEVPLPPEQAWEYASDLSRYHEWLSIHRAWRSKLPETLEKGTVIESIVEVKGMLNRVRWTLVHYKPPQALTLN
GDGRGGVKVKLIGKIKPTDNGATVGFDLHLGGPALFGPIGMVVAAALKSDIQESLNRFKQLYAPSAT

Download         Length: 444 bp

Antitoxin


Download         Length: 63 a.a.        Molecular weight: 6867.59 Da        Isoelectric Point: 4.6868

>AT253464 WP_011730673.1 NZ_CP102347:c5734424-5734236 [Mycolicibacterium smegmatis]
MGFLDKAKDLLSQNADKVDTVIDKAGDMIDEKTQGKYAQHVDKAQDAAKNAIHKDDPQEPQQ

Download         Length: 189 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A653F9V2

References