Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Fic(toxin)
Location 1369876..1370462 Replicon chromosome
Accession NZ_CP102347
Organism Mycolicibacterium smegmatis strain LM14

Toxin (Protein)


Gene name doc Uniprot ID A0A8B4QHV5
Locus tag NQ427_RS06300 Protein ID WP_011727560.1
Coordinates 1370070..1370462 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A2U9PKT9
Locus tag NQ427_RS06295 Protein ID WP_011727559.1
Coordinates 1369876..1370073 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQ427_RS06270 (NQ427_06270) 1364909..1366387 - 1479 WP_011727554.1 ADP-ribosylglycohydrolase family protein -
NQ427_RS06275 (NQ427_06275) 1366576..1366917 - 342 WP_011727555.1 DUF732 domain-containing protein -
NQ427_RS06280 (NQ427_06280) 1366977..1368050 - 1074 WP_228025495.1 SMP-30/gluconolactonase/LRE family protein -
NQ427_RS06285 (NQ427_06285) 1368285..1369364 - 1080 WP_011727557.1 HNH endonuclease domain-containing protein -
NQ427_RS06290 (NQ427_06290) 1369432..1369728 + 297 WP_011727558.1 nucleoside triphosphate pyrophosphohydrolase -
NQ427_RS06295 (NQ427_06295) 1369876..1370073 + 198 WP_011727559.1 type II toxin-antitoxin system antitoxin Phd Antitoxin
NQ427_RS06300 (NQ427_06300) 1370070..1370462 + 393 WP_011727560.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
NQ427_RS06305 (NQ427_06305) 1370539..1371969 + 1431 WP_003892661.1 DUF3375 domain-containing protein -
NQ427_RS06310 (NQ427_06310) 1371984..1372688 + 705 WP_234882670.1 DUF4194 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(49-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 13939.57 Da        Isoelectric Point: 4.2481

>T253460 WP_011727560.1 NZ_CP102347:1370070-1370462 [Mycolicibacterium smegmatis]
VTEYLDREDVLTAGSIAFGGELKVRDYGLLDAAVARPQATVYGVDAYPRLWDKAAALLQSLARNHALVDGNKRTAWAAAW
TFLHINGVQLAADFDVDRAEDLMNEVATRDCDLDSIAAELAGFAAAAQTG

Download         Length: 393 bp

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7276.30 Da        Isoelectric Point: 8.9353

>AT253460 WP_011727559.1 NZ_CP102347:1369876-1370073 [Mycolicibacterium smegmatis]
MPSLNIDFDEAEMEQIRAAARADDLSLKKFAHAAVMERASAHKRRVAEAARLVAERSAELNRRLA

Download         Length: 198 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4QHV5

Antitoxin

Source ID Structure
AlphaFold DB A0A2U9PKT9

References