Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 538355..538841 Replicon chromosome
Accession NC_015600
Organism Streptococcus pasteurianus ATCC 43144

Toxin (Protein)


Gene name relE Uniprot ID F5X5E2
Locus tag SGPB_RS02890 Protein ID WP_013851589.1
Coordinates 538572..538841 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID F5X5E1
Locus tag SGPB_RS02885 Protein ID WP_013851588.1
Coordinates 538355..538582 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SGPB_RS02860 533703..534023 + 321 WP_013851584.1 multidrug efflux SMR transporter -
SGPB_RS02865 534240..534932 + 693 WP_003063785.1 phosphoglycerate mutase -
SGPB_RS02870 535080..536243 - 1164 WP_013851585.1 site-specific integrase -
SGPB_RS02875 536391..536987 - 597 WP_013851586.1 helix-turn-helix domain-containing protein -
SGPB_RS02880 537139..537324 + 186 WP_013851587.1 hypothetical protein -
SGPB_RS02885 538355..538582 + 228 WP_013851588.1 hypothetical protein Antitoxin
SGPB_RS02890 538572..538841 + 270 WP_013851589.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SGPB_RS10530 539318..539860 - 543 Protein_516 DUF3267 domain-containing protein -
SGPB_RS02895 540134..540655 + 522 WP_003063789.1 transcription repressor NadR -
SGPB_RS02900 540852..541406 + 555 WP_013851590.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10500.51 Da        Isoelectric Point: 10.4700

>T25346 WP_013851589.1 NC_015600:538572-538841 [Streptococcus pasteurianus ATCC 43144]
MTYRLVVSDKVKKQLKKMDKHVRLMLAKDMKKHLDGVENPRQMGKALTGQFKGLWRYRIGNYRVICDIIDDDLVILAIEV
GHRKDIYKN

Download         Length: 270 bp

>T25346 NC_015600:538572-538841 [Streptococcus pasteurianus ATCC 43144]
ATGACTTATAGACTAGTTGTTAGCGATAAGGTCAAGAAACAGCTTAAGAAAATGGATAAGCATGTAAGGCTTATGCTTGC
TAAAGACATGAAAAAGCACCTTGACGGTGTAGAGAATCCTAGACAAATGGGAAAAGCATTAACAGGGCAATTCAAAGGTC
TATGGCGTTACAGAATAGGGAATTACAGGGTTATTTGTGATATTATAGATGATGATTTGGTTATCCTCGCTATCGAAGTA
GGACATAGAAAAGATATTTATAAAAATTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8675.72 Da        Isoelectric Point: 4.2808

>AT25346 WP_013851588.1 NC_015600:538355-538582 [Streptococcus pasteurianus ATCC 43144]
MSIVSLRLNKNEEELFKSYSIHTGKTLSELFKTALAEQIEDQLDYETGIKALNEFKKNPVTHSIDDIIEEFENDL

Download         Length: 228 bp

>AT25346 NC_015600:538355-538582 [Streptococcus pasteurianus ATCC 43144]
ATGTCAATCGTATCACTTAGACTAAATAAAAATGAAGAAGAGCTTTTTAAAAGTTATTCTATTCACACAGGAAAAACACT
ATCAGAGTTGTTTAAAACGGCTTTAGCTGAACAAATTGAAGACCAACTAGATTATGAAACAGGTATTAAAGCATTAAATG
AATTTAAAAAGAACCCTGTTACTCACTCTATTGATGACATTATTGAGGAGTTTGAAAATGACTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A135YV33

Antitoxin

Source ID Structure
AlphaFold DB A0A135YV28

References