Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 5733784..5734425 Replicon chromosome
Accession NZ_CP102345
Organism Mycolicibacterium smegmatis strain LM11

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag NQ424_RS27300 Protein ID WP_011730672.1
Coordinates 5733784..5734227 (-) Length 148 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID I7FKW8
Locus tag NQ424_RS27305 Protein ID WP_011730673.1
Coordinates 5734237..5734425 (-) Length 63 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQ424_RS27280 (NQ424_27280) 5729267..5730004 + 738 WP_011730668.1 GntR family transcriptional regulator -
NQ424_RS27285 (NQ424_27285) 5730006..5731538 + 1533 WP_011730669.1 cyclohexanecarboxylate-CoA ligase -
NQ424_RS27290 (NQ424_27290) 5731539..5732312 + 774 WP_011730670.1 SDR family oxidoreductase -
NQ424_RS27295 (NQ424_27295) 5732309..5733781 + 1473 WP_011730671.1 long-chain fatty acid--CoA ligase -
NQ424_RS27300 (NQ424_27300) 5733784..5734227 - 444 WP_011730672.1 SRPBCC family protein Toxin
NQ424_RS27305 (NQ424_27305) 5734237..5734425 - 189 WP_011730673.1 antitoxin Antitoxin
NQ424_RS27310 (NQ424_27310) 5734451..5736826 - 2376 WP_011730674.1 cation-translocating P-type ATPase -
NQ424_RS27315 (NQ424_27315) 5736840..5738447 - 1608 WP_162139558.1 serine hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-141)

Antitoxin

Antitoxin Rv0909/MT0933

(4-52)


Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 16157.75 Da        Isoelectric Point: 9.9432

>T253454 WP_011730672.1 NZ_CP102345:c5734227-5733784 [Mycolicibacterium smegmatis]
MAKLSVSVEVPLPPEQAWEYASDLSRYHEWLSIHRAWRSKLPETLEKGTVIESIVEVKGMLNRVRWTLVHYKPPQALTLN
GDGRGGVKVKLIGKIKPTDNGATVGFDLHLGGPALFGPIGMVVAAALKSDIQESLNRFKQLYAPSAT

Download         Length: 444 bp

Antitoxin


Download         Length: 63 a.a.        Molecular weight: 6867.59 Da        Isoelectric Point: 4.6868

>AT253454 WP_011730673.1 NZ_CP102345:c5734425-5734237 [Mycolicibacterium smegmatis]
MGFLDKAKDLLSQNADKVDTVIDKAGDMIDEKTQGKYAQHVDKAQDAAKNAIHKDDPQEPQQ

Download         Length: 189 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A653F9V2

References