Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1377107..1377750 Replicon chromosome
Accession NZ_CP102344
Organism Mycolicibacterium smegmatis strain LM12

Toxin (Protein)


Gene name vapC Uniprot ID A0A8B4QHE7
Locus tag NQ425_RS06330 Protein ID WP_011727564.1
Coordinates 1377361..1377750 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0QRY5
Locus tag NQ425_RS06325 Protein ID WP_003892665.1
Coordinates 1377107..1377361 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQ425_RS06315 (NQ425_06315) 1372573..1375920 + 3348 WP_014877022.1 ATP-binding protein -
NQ425_RS06320 (NQ425_06320) 1375917..1377086 + 1170 WP_011727563.1 DUF3322 and DUF2220 domain-containing protein -
NQ425_RS06325 (NQ425_06325) 1377107..1377361 + 255 WP_003892665.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NQ425_RS06330 (NQ425_06330) 1377361..1377750 + 390 WP_011727564.1 type II toxin-antitoxin system VapC family toxin Toxin
NQ425_RS06335 (NQ425_06335) 1377769..1380174 - 2406 WP_011727565.1 SEC-C metal-binding domain-containing protein -
NQ425_RS06340 (NQ425_06340) 1380196..1381956 - 1761 WP_011727566.1 sulfatase-like hydrolase/transferase -
NQ425_RS06345 (NQ425_06345) 1381953..1382390 - 438 WP_011727567.1 SRPBCC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-123)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13909.73 Da        Isoelectric Point: 4.7222

>T253446 WP_011727564.1 NZ_CP102344:1377361-1377750 [Mycolicibacterium smegmatis]
MVIDTSALVAILTDEPDAELLEGAVADDPVRTMSTASYLETAIVIESRFGEPGGRELDLWLHRASVALVAVDADQADAAR
LAYRRYGKGRHRAGLNYGDCFSYALAKVSGQPLLFKGEAFRLTDVAAVH

Download         Length: 390 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9279.72 Da        Isoelectric Point: 8.0238

>AT253446 WP_003892665.1 NZ_CP102344:1377107-1377361 [Mycolicibacterium smegmatis]
MALSIKHPEADRLARELAARTGETLTEAVVMALRERLARTVGRTQVVPLREELAAIRRRCAALPVLDDRTAESILGYDDR
GLPS

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4QHE7

Antitoxin

Source ID Structure
AlphaFold DB A0QRY5

References