Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 2145932..2147153 Replicon chromosome
Accession NZ_CP102330
Organism Burkholderia cepacia strain N3009-2YT

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NQK75_RS26450 Protein ID WP_257249898.1
Coordinates 2146572..2147153 (+) Length 194 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A105CX23
Locus tag NQK75_RS26445 Protein ID WP_059553061.1
Coordinates 2145932..2146489 (+) Length 186 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQK75_RS26420 2141328..2142059 - 732 WP_006498851.1 ribonuclease T2 -
NQK75_RS26425 2142290..2142679 + 390 WP_021162776.1 OsmC family protein -
NQK75_RS26430 2142761..2143339 - 579 WP_059812773.1 hypothetical protein -
NQK75_RS26435 2143436..2144839 - 1404 WP_257249896.1 DUF308 domain-containing protein -
NQK75_RS26440 2145200..2145877 + 678 WP_257249897.1 hypothetical protein -
NQK75_RS26445 2145932..2146489 + 558 WP_059553061.1 helix-turn-helix transcriptional regulator Antitoxin
NQK75_RS26450 2146572..2147153 + 582 WP_257249898.1 HD domain-containing protein Toxin
NQK75_RS26455 2147209..2147937 + 729 WP_060056885.1 class I SAM-dependent methyltransferase -
NQK75_RS26460 2148225..2149418 + 1194 WP_059485166.1 macrolide transporter subunit MacA -
NQK75_RS26465 2149421..2151481 + 2061 WP_257249899.1 MacB family efflux pump subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-172)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-64)


Sequences

Toxin        


Download         Length: 194 a.a.        Molecular weight: 21284.92 Da        Isoelectric Point: 5.2812

>T253433 WP_257249898.1 NZ_CP102330:2146572-2147153 [Burkholderia cepacia]
MNPDTIHARLAFLREAERLKDVLRSGHTSAGRAESTAEHSWRLCLMALVFADALPGIDTLKLLKLCVVHDLGEVLHGDIP
AIEQAAHPDKSAHERDDLLTLTAPLDPAQRDEIVALWDEYEAAASPEARAAKAFDKLETILQHTQGRNPPGFDYAFNLGY
GRRYTDAAPLFSAIRDIVDADTQRRIDASGQHA

Download         Length: 582 bp

Antitoxin


Download         Length: 186 a.a.        Molecular weight: 20097.06 Da        Isoelectric Point: 10.2051

>AT253433 WP_059553061.1 NZ_CP102330:2145932-2146489 [Burkholderia cepacia]
MSASPLHTPPLGPQLKRWRALHRVKQSHAAELFGVAQSTISRWEAGLQQMSPGERATAERLLAARLDSAGDHALARLVAG
SAGRMHLVCDLTHRLLACSPARAAEFSQPLSMLLGTSLWRYATPEIVRMETALDTLGWHDRAGPPSVEFDTGANASRVVP
IRGSLCRWTRMTLSDGSAARLVETL

Download         Length: 558 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A105CX23

References