Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1814040..1815790 Replicon chromosome
Accession NZ_CP102330
Organism Burkholderia cepacia strain N3009-2YT

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag NQK75_RS24910 Protein ID WP_257249803.1
Coordinates 1814894..1815790 (-) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A365QHE5
Locus tag NQK75_RS24905 Protein ID WP_059497041.1
Coordinates 1814040..1814897 (-) Length 286 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQK75_RS24885 1809203..1810693 - 1491 WP_059484807.1 aldehyde dehydrogenase -
NQK75_RS24890 1810766..1811593 - 828 WP_021161508.1 aspartate dehydrogenase -
NQK75_RS24895 1811586..1813253 - 1668 WP_257249800.1 thiamine pyrophosphate-binding protein -
NQK75_RS24900 1813246..1814043 - 798 WP_257249801.1 SDR family oxidoreductase -
NQK75_RS24905 1814040..1814897 - 858 WP_059497041.1 IclR family transcriptional regulator Antitoxin
NQK75_RS24910 1814894..1815790 - 897 WP_257249803.1 alpha/beta fold hydrolase Toxin
NQK75_RS24915 1815809..1816336 - 528 WP_021161513.1 cupin domain-containing protein -
NQK75_RS24920 1816375..1817145 - 771 WP_048022637.1 SDR family oxidoreductase -
NQK75_RS24925 1817138..1818208 - 1071 WP_021161515.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
NQK75_RS24930 1818291..1818602 - 312 WP_059484801.1 hypothetical protein -
NQK75_RS24935 1818606..1818923 - 318 WP_021161517.1 non-heme iron oxygenase ferredoxin subunit -
NQK75_RS24940 1819018..1819344 - 327 WP_257249804.1 hypothetical protein -
NQK75_RS24945 1819369..1820448 + 1080 WP_176130833.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-279)

Antitoxin

Transcription regulator IclR, C-terminal

(143-266)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30559.77 Da        Isoelectric Point: 7.7326

>T253431 WP_257249803.1 NZ_CP102330:c1815790-1814894 [Burkholderia cepacia]
MSVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYREAGAQHGGRALPVVLLHGIGSGAASWVSQLDTLGASRRVLAW
DAPGYGVSTPVHGASPAAADYAAALNAWLEALGIERCVLVGHSLGAIIAGGLARVMPARIAGLLLISPAGGYGSAPADTR
ESRRDARLAMLAELGPAGLAEQRSGNMLSGFANEDARAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRGRTAVAVG
ANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPAVYSALIDTFCRQCDQQRGLA

Download         Length: 897 bp

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31546.09 Da        Isoelectric Point: 6.6572

>AT253431 WP_059497041.1 NZ_CP102330:c1814897-1814040 [Burkholderia cepacia]
MNEPLQRPEPENDKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQSPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELRSLYPEGTLNRMTNATPETVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNETQKIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFMKALGLR

Download         Length: 858 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A365QHE5

References