Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1814040..1815790 Replicon chromosome
Accession NZ_CP102330
Organism Burkholderia cepacia strain N3009-2YT

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag NQK75_RS24910 Protein ID WP_257249803.1
Coordinates 1814894..1815790 (-) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A365QHE5
Locus tag NQK75_RS24905 Protein ID WP_059497041.1
Coordinates 1814040..1814897 (-) Length 286 a.a.

Genomic Context


NQK75_RS24945NQK75_RS24885NQK75_RS24890NQK75_RS24895NQK75_RS24900NQK75_RS24905NQK75_RS24910NQK75_RS24915NQK75_RS24920NQK75_RS24925NQK75_RS24930NQK75_RS24935NQK75_RS24940
Location: 1819369..1820448 (1080 bp)
Type: Others
Protein ID: WP_176130833.1
Location: 1809203..1810693 (1491 bp)
Type: Others
Protein ID: WP_059484807.1
Location: 1810766..1811593 (828 bp)
Type: Others
Protein ID: WP_021161508.1
Location: 1811586..1813253 (1668 bp)
Type: Others
Protein ID: WP_257249800.1
Location: 1813246..1814043 (798 bp)
Type: Others
Protein ID: WP_257249801.1
Location: 1814040..1814897 (858 bp)
Type: Antitoxin
Protein ID: WP_059497041.1
Location: 1814894..1815790 (897 bp)
Type: Toxin
Protein ID: WP_257249803.1
Location: 1815809..1816336 (528 bp)
Type: Others
Protein ID: WP_021161513.1
Location: 1816375..1817145 (771 bp)
Type: Others
Protein ID: WP_048022637.1
Location: 1817138..1818208 (1071 bp)
Type: Others
Protein ID: WP_021161515.1
Location: 1818291..1818602 (312 bp)
Type: Others
Protein ID: WP_059484801.1
Location: 1818606..1818923 (318 bp)
Type: Others
Protein ID: WP_021161517.1
Location: 1819018..1819344 (327 bp)
Type: Others
Protein ID: WP_257249804.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
NQK75_RS248851809203..1810693-1491WP_059484807.1aldehyde dehydrogenase-
NQK75_RS248901810766..1811593-828WP_021161508.1aspartate dehydrogenase-
NQK75_RS248951811586..1813253-1668WP_257249800.1thiamine pyrophosphate-binding protein-
NQK75_RS249001813246..1814043-798WP_257249801.1SDR family oxidoreductase-
NQK75_RS249051814040..1814897-858WP_059497041.1IclR family transcriptional regulatorAntitoxin
NQK75_RS249101814894..1815790-897WP_257249803.1alpha/beta fold hydrolaseToxin
NQK75_RS249151815809..1816336-528WP_021161513.1cupin domain-containing protein-
NQK75_RS249201816375..1817145-771WP_048022637.1SDR family oxidoreductase-
NQK75_RS249251817138..1818208-1071WP_021161515.1aromatic ring-hydroxylating dioxygenase subunit alpha-
NQK75_RS249301818291..1818602-312WP_059484801.1hypothetical protein-
NQK75_RS249351818606..1818923-318WP_021161517.1non-heme iron oxygenase ferredoxin subunit-
NQK75_RS249401819018..1819344-327WP_257249804.1hypothetical protein-
NQK75_RS249451819369..1820448+1080WP_176130833.1porin-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(51-279)

Antitoxin

(143-266)


Sequences


Toxin        


Download         Length: 299 a.a.        Molecular weight: 30559.77 Da        Isoelectric Point: 7.7326

>T253431 WP_257249803.1 NZ_CP102330:c1815790-1814894 [Burkholderia cepacia]
MSVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYREAGAQHGGRALPVVLLHGIGSGAASWVSQLDTLGASRRVLAW
DAPGYGVSTPVHGASPAAADYAAALNAWLEALGIERCVLVGHSLGAIIAGGLARVMPARIAGLLLISPAGGYGSAPADTR
ESRRDARLAMLAELGPAGLAEQRSGNMLSGFANEDARAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRGRTAVAVG
ANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPAVYSALIDTFCRQCDQQRGLA

Download         Length: 897 bp


Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31546.09 Da        Isoelectric Point: 6.6572

>AT253431 WP_059497041.1 NZ_CP102330:c1814897-1814040 [Burkholderia cepacia]
MNEPLQRPEPENDKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQSPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELRSLYPEGTLNRMTNATPETVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNETQKIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFMKALGLR

Download         Length: 858 bp


Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
No matching records found


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A365QHE5

References