Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 791491..792068 Replicon chromosome
Accession NZ_CP102330
Organism Burkholderia cepacia strain N3009-2YT

Toxin (Protein)


Gene name vapC Uniprot ID U2G063
Locus tag NQK75_RS20490 Protein ID WP_021160897.1
Coordinates 791491..791856 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U2HEK9
Locus tag NQK75_RS20495 Protein ID WP_021160898.1
Coordinates 791850..792068 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQK75_RS20470 787120..787674 + 555 WP_257250516.1 carboxymuconolactone decarboxylase family protein -
NQK75_RS20475 787835..788635 + 801 WP_257250517.1 extensin -
NQK75_RS20480 788871..790469 - 1599 WP_059552487.1 alkyl hydroperoxide reductase subunit F -
NQK75_RS20485 790592..791155 - 564 WP_006488685.1 alkyl hydroperoxide reductase subunit C -
NQK75_RS20490 791491..791856 - 366 WP_021160897.1 type II toxin-antitoxin system VapC family toxin Toxin
NQK75_RS20495 791850..792068 - 219 WP_021160898.1 hypothetical protein Antitoxin
NQK75_RS20500 792159..793055 - 897 WP_048026027.1 LysR substrate-binding domain-containing protein -
NQK75_RS20505 793233..794399 + 1167 WP_257250526.1 branched-chain amino acid ABC transporter substrate-binding protein -
NQK75_RS20510 794459..794983 + 525 WP_257250527.1 L-2-amino-thiazoline-4-carboxylic acid hydrolase -
NQK75_RS20515 794976..796241 + 1266 WP_059677103.1 Zn-dependent hydrolase -
NQK75_RS20520 796329..796811 - 483 WP_048026029.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-106)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13448.50 Da        Isoelectric Point: 8.4389

>T253429 WP_021160897.1 NZ_CP102330:c791856-791491 [Burkholderia cepacia]
MVKALFDTNILIDYLGGVESARAELGRYDYRAISTISWMEVLVGTSAQDEAPIRAWLSSFDVIALDSPVANRAVTIRKER
RIRLPDAIVWASAQVNGLLLVSRNTKDFPATEPGVRVPYKL

Download         Length: 366 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8372.51 Da        Isoelectric Point: 5.0604

>AT253429 WP_021160898.1 NZ_CP102330:c792068-791850 [Burkholderia cepacia]
MSRILVDLSDGQLDELAVIVETQHRPRAAIIRDAIDAYIALHKHRLADDVFGLWKDRKVDGLTYQEELRSEW

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U2G063

Antitoxin

Source ID Structure
AlphaFold DB U2HEK9

References