Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 409302..409922 Replicon chromosome
Accession NZ_CP102330
Organism Burkholderia cepacia strain N3009-2YT

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag NQK75_RS18835 Protein ID WP_021157289.1
Coordinates 409605..409922 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U2GAF3
Locus tag NQK75_RS18830 Protein ID WP_021157290.1
Coordinates 409302..409601 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQK75_RS18805 404416..405687 + 1272 WP_059857507.1 anthranilate 1,2-dioxygenase large subunit AndAc -
NQK75_RS18810 405705..406190 + 486 WP_048022184.1 anthranilate 1,2-dioxygenase small subunit AndAd -
NQK75_RS18815 406211..406537 + 327 WP_006479527.1 anthranilate 1,2-dioxygenase ferredoxin subunit AndAb -
NQK75_RS18820 406527..407747 + 1221 WP_257250406.1 anthranilate 1,2-dioxygenase system ferredoxin--NAD(+) reductase -
NQK75_RS18825 407959..409245 + 1287 WP_257250408.1 DUF445 domain-containing protein -
NQK75_RS18830 409302..409601 - 300 WP_021157290.1 putative addiction module antidote protein Antitoxin
NQK75_RS18835 409605..409922 - 318 WP_021157289.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NQK75_RS18840 410283..411923 + 1641 WP_021157288.1 acetolactate synthase large subunit -
NQK75_RS18845 411952..413385 + 1434 WP_257250409.1 aldehyde dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(19-91)

Antitoxin

Uncharacterized protein HI1420

(6-93)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11866.62 Da        Isoelectric Point: 9.9423

>T253428 WP_021157289.1 NZ_CP102330:c409922-409605 [Burkholderia cepacia]
MPYSAPTFSIRTTDVFDAWFAGLRDRVAKRRIQARIDRLSMGNPGDWKSAGSPVVEMRIDHGPGYRVYYVRRGTIWVILL
CGGDKSTQQADIRAAHAMLAHLDME

Download         Length: 318 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10633.01 Da        Isoelectric Point: 6.3217

>AT253428 WP_021157290.1 NZ_CP102330:c409601-409302 [Burkholderia cepacia]
MDKISTRPWDSADHLKTEDDMADYFEACLQEAGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAHA

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB U2GAF3

References