Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1823170..1823843 Replicon chromosome
Accession NZ_CP102329
Organism Burkholderia cepacia strain N3009-2YT

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag NQK75_RS08430 Protein ID WP_257248282.1
Coordinates 1823427..1823843 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID U2FLJ7
Locus tag NQK75_RS08425 Protein ID WP_021160097.1
Coordinates 1823170..1823430 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQK75_RS08410 1818725..1820977 + 2253 WP_257248280.1 TonB-dependent siderophore receptor -
NQK75_RS08415 1821064..1821903 + 840 WP_042975471.1 formyltransferase family protein -
NQK75_RS08420 1821903..1822919 + 1017 WP_257248281.1 GNAT family N-acetyltransferase -
NQK75_RS08425 1823170..1823430 + 261 WP_021160097.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NQK75_RS08430 1823427..1823843 + 417 WP_257248282.1 PIN domain-containing protein Toxin
NQK75_RS08435 1823892..1824797 - 906 WP_257248283.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
NQK75_RS08440 1824766..1825839 - 1074 WP_257249754.1 type IV toxin-antitoxin system AbiEi family antitoxin -
NQK75_RS08445 1826180..1827343 + 1164 WP_059484570.1 M20 aminoacylase family protein -
NQK75_RS08450 1827587..1828126 + 540 WP_257248284.1 outer membrane protein assembly factor BamE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-130)

Antitoxin

SpoVT-AbrB domain

(7-54)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14545.76 Da        Isoelectric Point: 7.2147

>T253427 WP_257248282.1 NZ_CP102329:1823427-1823843 [Burkholderia cepacia]
VTTLYMLDTNICSFIMRERPPVVLSRLQSCVNAQHRIVMSAITYAEMRFGAVGRKASPKHAELVTAFVSRLDGVLSWDTA
AVDATAAICADLAARGMPIGANDASIAGHAIAAGAVLVTNNGREFGRVAGLSLEDWAA

Download         Length: 417 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9546.80 Da        Isoelectric Point: 4.6151

>AT253427 WP_021160097.1 NZ_CP102329:1823170-1823430 [Burkholderia cepacia]
MRTVSIFKNARNQAIRIPKDMEFEGVTELEIRREGDTLLLRPVRPTWLSFASEPLADADFLAERPAVIESGRFDLSGGAA
PTESGQ

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB U2FLJ7

References