Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-vagC/VapC-VagC
Location 175314..175951 Replicon chromosome
Accession NZ_CP102329
Organism Burkholderia cepacia strain N3009-2YT

Toxin (Protein)


Gene name vapC Uniprot ID U2FRJ0
Locus tag NQK75_RS00775 Protein ID WP_021164186.1
Coordinates 175550..175951 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag NQK75_RS00770 Protein ID WP_042978332.1
Coordinates 175314..175550 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQK75_RS00755 170924..171955 + 1032 WP_124589456.1 helix-turn-helix domain-containing protein -
NQK75_RS00760 172089..173201 - 1113 WP_257248891.1 ADP-heptose--LPS heptosyltransferase -
NQK75_RS00765 173198..174901 - 1704 WP_059678233.1 thiamine pyrophosphate-binding protein -
NQK75_RS00770 175314..175550 + 237 WP_042978332.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NQK75_RS00775 175550..175951 + 402 WP_021164186.1 type II toxin-antitoxin system VapC family toxin Toxin
NQK75_RS00780 176019..177407 - 1389 WP_021164187.1 L-serine ammonia-lyase -
NQK75_RS00785 177438..178574 - 1137 WP_060049042.1 alginate lyase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-121)

Antitoxin

SpoVT-AbrB domain

(7-46)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15033.14 Da        Isoelectric Point: 5.2050

>T253426 WP_021164186.1 NZ_CP102329:175550-175951 [Burkholderia cepacia]
MPRYMLDTNMCIYLMKHQPEQVAKRFAQCYTGDVVMSAITYAELEYGVAACANAVRERRNLADLIEDIPVAPFDAAAAQA
YGPVREATRERKRDHLDKLIAAHAVSLDVVLVTNNERDFASYPGLRLENWLND

Download         Length: 402 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8926.06 Da        Isoelectric Point: 5.1651

>AT253426 WP_042978332.1 NZ_CP102329:175314-175550 [Burkholderia cepacia]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERIGDEIRIRPVRRPLAGVLEKFAKFAPDFMAEGRGDQEQADREGL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U2FRJ0

Antitoxin

Source ID Structure

References