Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4559262..4560401 Replicon chromosome
Accession NZ_CP102328
Organism Pseudomonas otitidis strain BC12

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag NRL37_RS20875 Protein ID WP_268195475.1
Coordinates 4559262..4560011 (-) Length 250 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A1E4WFB3
Locus tag NRL37_RS20880 Protein ID WP_044405544.1
Coordinates 4560030..4560401 (-) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NRL37_RS20865 (NRL37_20865) 4556933..4558408 - 1476 WP_268192985.1 DNA recombination protein RmuC -
NRL37_RS20870 (NRL37_20870) 4558461..4558874 - 414 WP_268192986.1 sel1 repeat family protein -
NRL37_RS20875 (NRL37_20875) 4559262..4560011 - 750 WP_268195475.1 RES family NAD+ phosphorylase Toxin
NRL37_RS20880 (NRL37_20880) 4560030..4560401 - 372 WP_044405544.1 XRE family transcriptional regulator Antitoxin
NRL37_RS20885 (NRL37_20885) 4560534..4561016 + 483 WP_268192987.1 GreA/GreB family elongation factor -
NRL37_RS20890 (NRL37_20890) 4561053..4561448 + 396 WP_044405547.1 hypothetical protein -
NRL37_RS20895 (NRL37_20895) 4561674..4561826 + 153 WP_182852994.1 hypothetical protein -
NRL37_RS20900 (NRL37_20900) 4561854..4562279 - 426 WP_074971868.1 S24 family peptidase -
NRL37_RS20905 (NRL37_20905) 4562389..4563993 - 1605 WP_074971869.1 M28 family metallopeptidase -
NRL37_RS20910 (NRL37_20910) 4564269..4564934 - 666 WP_044405551.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(58-205)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 250 a.a.        Molecular weight: 28120.10 Da        Isoelectric Point: 7.3511

>T253425 WP_268195475.1 NZ_CP102328:c4560011-4559262 [Pseudomonas otitidis]
MDIWSACDGERHIAPLRGRVVRLVESQEQVATLQLVDNLAEQALLEELIETSKPPLPRSAEPLHYLLKTPFRYPPLRWGS
RFGTVHEPSLFYAAARLETAMAEGAFYRFVLWSGMATPPPSGRILSEHASFEARFQVMRGVSLQTPPFDAYPALLDRRDY
RATQALGAAMRAAGVEAFEYRSARCPQQGLNIALFTPDAFTERRPRNLTPWFCETTADYVAYKHAQAPDQPRLFRREAFL
VDGVIPQPA

Download         Length: 750 bp

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 13690.98 Da        Isoelectric Point: 10.6556

>AT253425 WP_044405544.1 NZ_CP102328:c4560401-4560030 [Pseudomonas otitidis]
MSALTRPHLDPDAVLAKALLNTREQLGLTRQQLADIVGVHRTVVTRWADAGSIRPQSKTGELALLVIRIYRALFALFGGN
LEDMRHFLRTENRHLGGVPLELMGQVQGLVRVVEYLDAIRGKV

Download         Length: 372 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1E4WFB3

References