Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1507332..1508925 Replicon chromosome
Accession NZ_CP102327
Organism Aeromonas dhakensis strain BC05

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NRL00_RS06950 Protein ID WP_017765666.1
Coordinates 1507332..1508648 (-) Length 439 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NRL00_RS06955 Protein ID WP_041202615.1
Coordinates 1508632..1508925 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NRL00_RS06925 (NRL00_06925) 1502708..1503862 - 1155 WP_268010468.1 ElyC/SanA/YdcF family protein -
NRL00_RS06930 (NRL00_06930) 1504345..1505556 + 1212 WP_017765670.1 NupC/NupG family nucleoside CNT transporter -
NRL00_RS06935 (NRL00_06935) 1505738..1506181 + 444 WP_049048861.1 inhibitor of vertebrate lysozyme family protein -
NRL00_RS06940 (NRL00_06940) 1506251..1506793 - 543 WP_268010469.1 beta/gamma crystallin-related protein -
NRL00_RS06945 (NRL00_06945) 1506991..1507233 - 243 WP_005302916.1 DUF3297 family protein -
NRL00_RS06950 (NRL00_06950) 1507332..1508648 - 1317 WP_017765666.1 HipA domain-containing protein Toxin
NRL00_RS06955 (NRL00_06955) 1508632..1508925 - 294 WP_041202615.1 helix-turn-helix domain-containing protein Antitoxin
NRL00_RS06960 (NRL00_06960) 1509206..1509763 + 558 WP_268010470.1 metal-dependent hydrolase -
NRL00_RS06965 (NRL00_06965) 1509720..1510469 - 750 WP_071915111.1 hypothetical protein -
NRL00_RS06970 (NRL00_06970) 1510497..1510847 - 351 WP_158508567.1 lysozyme inhibitor LprI family protein -
NRL00_RS06975 (NRL00_06975) 1511070..1511759 - 690 WP_213343869.1 hypothetical protein -
NRL00_RS06980 (NRL00_06980) 1511890..1512204 + 315 Protein_1348 metal-dependent hydrolase -
NRL00_RS06985 (NRL00_06985) 1512356..1513039 - 684 WP_268010471.1 hypothetical protein -
NRL00_RS06990 (NRL00_06990) 1513124..1513906 - 783 WP_268010472.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(11-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-73)


Sequences

Toxin        


Download         Length: 439 a.a.        Molecular weight: 49597.67 Da        Isoelectric Point: 6.0490

>T253423 WP_017765666.1 NZ_CP102327:c1508648-1507332 [Aeromonas dhakensis]
MMNGSEHHRLELRLGNQLIGHLEYDSNRDSFQLGYLPEWQARGFPLSPPLALDGSASSAQIRAYLGNLLPENRGLDHLIE
VLSVSRSNLFALIHGIGRDVSGAVTFTLPAEPDIPTRFRPITPEELMLRLDQPEIWPLEVWDGRPRLSVAGVQAKLNLLR
LEGRLGFGEGELCSTHLLKFEHHPHLVINEFVTMQLAAQLSMPVARVELHTVGQGEKSHRSLLVERFDRRLDEDGMRVRR
RHMIDACQGLGFPVARKYERNFGDGRDVAHIREGVSLPRLFSLSALCVNPAQARLDMLQWLLFNLCVNNHDAHGKNYSFF
VSKAGLTPTPWYDLVNVGLYPEFNQHLAMAIGDEFAPEAINAWQLLEMAEACDLPERLLQQTLQKIASDILHHLDAAIAM
VETDHPAELDYLARYKDDVERRCHHFQEQAGLLPELQL

Download         Length: 1317 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10570.25 Da        Isoelectric Point: 6.2983

>AT253423 WP_041202615.1 NZ_CP102327:c1508925-1508632 [Aeromonas dhakensis]
MTDTPLPTGTKELDPASLGLAIRERRKAAKMTQEVTASLCGISKKTLIKIEKGGDVYLSTLLQVMKALGLRLQLVQEAGS
QVMSSYSQPEVGDDEWF

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References