Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4913482..4915055 Replicon chromosome
Accession NZ_CP102326
Organism Aeromonas dhakensis strain BC04

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NRK99_RS22650 Protein ID WP_126880819.1
Coordinates 4913482..4914801 (-) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NRK99_RS22655 Protein ID WP_017410478.1
Coordinates 4914801..4915055 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NRK99_RS22635 (NRK99_22635) 4909374..4910138 + 765 WP_126880827.1 ATP-binding cassette domain-containing protein -
NRK99_RS22640 (NRK99_22640) 4910157..4911083 + 927 WP_126880826.1 ABC transporter substrate-binding protein -
NRK99_RS22645 (NRK99_22645) 4911080..4913062 + 1983 WP_268000224.1 Fe(3+)-hydroxamate ABC transporter permease FhuB -
NRK99_RS22650 (NRK99_22650) 4913482..4914801 - 1320 WP_126880819.1 type II toxin-antitoxin system HipA family toxin Toxin
NRK99_RS22655 (NRK99_22655) 4914801..4915055 - 255 WP_017410478.1 helix-turn-helix domain-containing protein Antitoxin
NRK99_RS22660 (NRK99_22660) 4915604..4915678 + 75 Protein_4369 EAL domain-containing protein -
NRK99_RS22665 (NRK99_22665) 4915818..4916582 - 765 WP_001389365.1 IS6-like element IS6100 family transposase -
NRK99_RS22670 (NRK99_22670) 4916700..4916768 - 69 Protein_4371 hypothetical protein -
NRK99_RS22675 (NRK99_22675) 4917089..4917589 - 501 WP_000376623.1 GNAT family N-acetyltransferase -
NRK99_RS22680 (NRK99_22680) 4917717..4918556 - 840 WP_000259031.1 sulfonamide-resistant dihydropteroate synthase Sul1 -
NRK99_RS22685 (NRK99_22685) 4918550..4918897 - 348 WP_000679427.1 quaternary ammonium compound efflux SMR transporter QacE delta 1 -
NRK99_RS22690 (NRK99_22690) 4919014..4919852 - 839 Protein_4375 ANT(3'')-Ia family aminoglycoside nucleotidyltransferase AadA1 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(150-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49489.44 Da        Isoelectric Point: 6.6626

>T253422 WP_126880819.1 NZ_CP102326:c4914801-4913482 [Aeromonas dhakensis]
MANLAVYMNGYRVGTFTKTTSGAHQFQYHESWLAQPGSRPISLSMPLRHQAYRGDEAYNFFDNLLPDNTEVRNRVVARYQ
AASTQPFDLLSCIGQDSVGALQLVTEGHDVPDVRRIDYKALSDDELEQILTSYKSGIPLGMVREQEEFRISIAGAQEKTA
LLYIDGRWYLPLKATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKEFGLPVPHCFMMQVGQVKALAVERFDRR
YAADRSWIMRLPQEDFCQVLNVPSARKYESHGGPGITDIMKTLLGSATPEQDGYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSVYPVFGGRGLNRRDAKLAMGLASSKGKKYSIEQIFPRHFFQTAKTVGFERSAMEEILTELANSV
DDVIERVTQQLPADFPDTISSTILEGLKARSARLIKGWD

Download         Length: 1320 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9293.62 Da        Isoelectric Point: 7.9834

>AT253422 WP_017410478.1 NZ_CP102326:c4915055-4914801 [Aeromonas dhakensis]
MKVTSAKQLSACIKDARLSQKLSQGKVAEKVGIRQDTVSSFELNPESTKLETLFKILAALELSVDIKPRNESSESPASGW
KEEW

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References