Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1549435..1551028 Replicon chromosome
Accession NZ_CP102326
Organism Aeromonas dhakensis strain BC04

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NRK99_RS07285 Protein ID WP_268000683.1
Coordinates 1549435..1550751 (-) Length 439 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NRK99_RS07290 Protein ID WP_041202615.1
Coordinates 1550735..1551028 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NRK99_RS07260 (NRK99_07260) 1544811..1545965 - 1155 WP_198527771.1 YdcF family protein -
NRK99_RS07265 (NRK99_07265) 1546448..1547659 + 1212 WP_054544453.1 NupC/NupG family nucleoside CNT transporter -
NRK99_RS07270 (NRK99_07270) 1547841..1548284 + 444 WP_054544454.1 inhibitor of vertebrate lysozyme family protein -
NRK99_RS07275 (NRK99_07275) 1548354..1548896 - 543 WP_054544455.1 beta/gamma crystallin-related protein -
NRK99_RS07280 (NRK99_07280) 1549094..1549336 - 243 WP_005302916.1 DUF3297 family protein -
NRK99_RS07285 (NRK99_07285) 1549435..1550751 - 1317 WP_268000683.1 HipA domain-containing protein Toxin
NRK99_RS07290 (NRK99_07290) 1550735..1551028 - 294 WP_041202615.1 helix-turn-helix domain-containing protein Antitoxin
NRK99_RS07295 (NRK99_07295) 1551309..1551842 + 534 WP_268000684.1 metal-dependent hydrolase -
NRK99_RS07300 (NRK99_07300) 1552074..1552532 - 459 WP_268000685.1 hypothetical protein -
NRK99_RS07305 (NRK99_07305) 1552646..1553443 - 798 WP_268000686.1 nucleotide-binding protein -
NRK99_RS07310 (NRK99_07310) 1553995..1554801 - 807 WP_268000687.1 tryptophan synthase subunit alpha -
NRK99_RS07315 (NRK99_07315) 1554798..1555991 - 1194 WP_201881463.1 tryptophan synthase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(11-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-73)


Sequences

Toxin        


Download         Length: 439 a.a.        Molecular weight: 49587.63 Da        Isoelectric Point: 6.0490

>T253421 WP_268000683.1 NZ_CP102326:c1550751-1549435 [Aeromonas dhakensis]
MMNGSEHHRLELRLGNQLIGHLEYDSNRDSFQLGYLPEWQARGFPLSPPLALDGSASSAQIRAYLGNLLPENRGLDHLIE
VLSVSRSNLFALIHGIGRDVSGAVTFTLPAEPDIPTRFRPITPEELMLRLDQPEIWPLEVWDGRSRLSVAGVQAKLNLLR
LEGRLGFGEGELCSTHLLKFEHHPHLVINEFVTMQLAAQLSMPVARVELHTVGQGEKSHRSLLVERFDRRLDEDGMRVRR
RHMIDACQGLGFPVARKYERNFGDGRDVAHIREGVSLPRLFSLSALCVNPAQARLDMLQWLLFNLCVNNHDAHGKNYSFF
VSKAGLTPTPWYDLVNVGLYPEFNQHLAMAIGDEFAPEAINAWQLLEMAEACDLPERLLQQTLQKIASDILHHLDAAIAM
VETDHPAELDYLARYKDDVERRCHHFQEQAGLLPELQL

Download         Length: 1317 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10570.25 Da        Isoelectric Point: 6.2983

>AT253421 WP_041202615.1 NZ_CP102326:c1551028-1550735 [Aeromonas dhakensis]
MTDTPLPTGTKELDPASLGLAIRERRKAAKMTQEVTASLCGISKKTLIKIEKGGDVYLSTLLQVMKALGLRLQLVQEAGS
QVMSSYSQPEVGDDEWF

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References