Detailed information of TA system TA025342

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-Xre
• Location: 1398544..1399476
• Replicon: chromosome
• Accession: NC_015596
• Organism: Sinorhizobium meliloti AK83

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: SINME_RS24860
• Protein ID: WP_013850799.1
• Coordinates: 1398544..1399098 (-)
• Length: 185 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: H0G7T7
• Locus tag: SINME_RS24865
• Protein ID: WP_003534594.1
• Coordinates: 1399105..1399476 (-)
• Length: 124 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SINME_RS24840	1394192..1395058	+	867	WP_013850795.1	sulfate ABC transporter permease subunit CysT	-
SINME_RS24845	1395048..1395923	+	876	WP_013850796.1	sulfate ABC transporter permease subunit CysW	-
SINME_RS24850	1395939..1397045	+	1107	WP_013850797.1	sulfate/molybdate ABC transporter ATP-binding protein	-
SINME_RS24855	1397156..1398526	+	1371	WP_013850798.1	FAD-binding oxidoreductase	-
SINME_RS24860	1398544..1399098	-	555	WP_013850799.1	RES family NAD+ phosphorylase	Toxin
SINME_RS24865	1399105..1399476	-	372	WP_003534594.1	DUF2384 domain-containing protein	Antitoxin
SINME_RS24870	1399553..1400338	-	786	WP_013850800.1	crotonase/enoyl-CoA hydratase family protein	-
SINME_RS24875	1400335..1401204	-	870	WP_013850801.1	hydroxymethylglutaryl-CoA lyase	-
SINME_RS24880	1401201..1403189	-	1989	WP_013850802.1	acetyl/propionyl/methylcrotonyl-CoA carboxylase subunit alpha	-
SINME_RS24885	1403206..1403589	-	384	WP_013850803.1	RidA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (23-177)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (71-120)

Sequences

Toxin

Protein

• Length: 185 a.a.
• Molecular weight: 20300.18 Da
• Isoelectric Point: 6.4890

>T25342 WP_013850799.1 NC_015596:c1399098-1398544 [Sinorhizobium meliloti AK83]
MGKHIPPASRPDSELTPSVEPITLWRAFVPRWAHMPLSGAGAARFGGRWNPIGVPAIYAARELSTAWAEYNQGFVQHPAL
IVQLELRGPKLADLTDASVLLELGADEAIHRCEWRDALDKGAVPETHRLQSVLLARDYHGVIYPSFMSPGGTCVALWRWN
GPEEPRLDVIDPDGRLPKSPASWV

Nucleotide

• Length: 555 bp

>T25342 NC_015596:c1399098-1398544 [Sinorhizobium meliloti AK83]
ATGGGGAAACACATTCCGCCCGCATCGCGACCCGATTCGGAACTGACGCCGTCGGTCGAGCCGATAACGCTCTGGCGCGC
CTTCGTTCCACGCTGGGCGCATATGCCGTTATCCGGCGCGGGTGCCGCTCGCTTCGGTGGCCGCTGGAATCCGATCGGCG
TGCCTGCGATTTATGCCGCGCGCGAGCTTTCTACCGCCTGGGCTGAATATAATCAGGGTTTCGTCCAGCATCCGGCGCTC
ATCGTGCAGCTCGAGTTGCGCGGGCCGAAGCTCGCGGACCTCACGGATGCCAGCGTTCTTCTGGAGCTTGGTGCGGATGA
AGCGATCCATCGCTGCGAATGGCGTGATGCGCTCGACAAAGGCGCGGTGCCGGAGACCCACAGGCTCCAGTCCGTGCTTC
TGGCGCGCGACTATCACGGGGTGATCTATCCATCCTTCATGTCGCCCGGGGGCACCTGCGTCGCGCTCTGGCGCTGGAAC
GGTCCGGAAGAACCGCGCCTCGACGTCATCGATCCCGATGGCCGGCTGCCGAAATCGCCCGCCTCATGGGTTTGA

Antitoxin

Protein

• Length: 124 a.a.
• Molecular weight: 13113.26 Da
• Isoelectric Point: 9.9996

>AT25342 WP_003534594.1 NC_015596:c1399476-1399105 [Sinorhizobium meliloti AK83]
MMAVDFQIPAARFGDDHSPFLSARLVADRLGVTLAELAKLIGVARNTLTAKSGARKVDSALSKVVRILAMASEMAGDEAR
AVIWFKHQPIPGWAGKTAFDLVGEGKADKVLAYLESVRAGVYA

Nucleotide

• Length: 372 bp

>AT25342 NC_015596:c1399476-1399105 [Sinorhizobium meliloti AK83]
ATGATGGCCGTCGATTTTCAGATACCTGCAGCCCGTTTCGGGGACGATCATTCCCCGTTTCTCTCGGCCCGCCTTGTCGC
CGACCGGTTGGGCGTCACGCTCGCCGAACTCGCCAAGCTGATCGGTGTCGCCCGCAATACGCTGACGGCGAAGTCCGGCG
CCCGGAAGGTCGACAGCGCCTTGAGCAAGGTCGTCCGCATCCTCGCCATGGCTTCGGAAATGGCGGGCGATGAAGCCCGC
GCCGTCATCTGGTTCAAGCACCAGCCTATCCCCGGCTGGGCAGGCAAGACGGCATTCGACCTGGTCGGCGAGGGCAAGGC
CGACAAGGTGCTCGCCTATCTCGAATCGGTACGTGCCGGCGTCTACGCCTAA

Structures

Antitoxin

• AlphaFold DB: H0G7T7