253418

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 1763769..1764300 Replicon chromosome
Accession NZ_CP102293
Organism Subdoligranulum variabile strain DSM 15176

Toxin (Protein)


Gene name relE Uniprot ID D1PSN4
Locus tag NQ490_RS08465 Protein ID WP_007048762.1
Coordinates 1763769..1764041 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag NQ490_RS08470 Protein ID WP_040918972.1
Coordinates 1764028..1764300 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQ490_RS08445 (NQ490_08445) 1759266..1759709 + 444 WP_040918496.1 phage holin family protein -
NQ490_RS08450 (NQ490_08450) 1759898..1761115 + 1218 WP_007048273.1 BTAD domain-containing putative transcriptional regulator -
NQ490_RS08455 (NQ490_08455) 1761182..1762855 - 1674 WP_007048272.1 phospho-sugar mutase -
NQ490_RS08465 (NQ490_08465) 1763769..1764041 - 273 WP_007048762.1 type II toxin-antitoxin system YafQ family toxin Toxin
NQ490_RS08470 (NQ490_08470) 1764028..1764300 - 273 WP_040918972.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NQ490_RS08475 (NQ490_08475) 1764543..1765388 - 846 WP_007048760.1 hypothetical protein -
NQ490_RS08480 (NQ490_08480) 1765424..1766395 - 972 WP_007048759.1 helix-turn-helix domain-containing protein -
NQ490_RS08485 (NQ490_08485) 1766458..1768326 - 1869 WP_040918970.1 type IV secretory system conjugative DNA transfer family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1748290..1799210 50920


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-83)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10630.30 Da        Isoelectric Point: 7.2405

>T253418 WP_007048762.1 NZ_CP102293:c1764041-1763769 [Subdoligranulum variabile]
MLTIKYQAAFKKDYKRIVKRGYDMRLLEKVIELLANQKPLPEKNRDHQLSGDYAGCRECHITPDWLLIYEVADEELILYL
TRTGSHSDLF

Download         Length: 273 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10070.46 Da        Isoelectric Point: 4.3774

>AT253418 WP_040918972.1 NZ_CP102293:c1764300-1764028 [Subdoligranulum variabile]
MANININIRMDSDLKQQFEAFCNDVGMTMTTAFTVFAKKAVREYRIPFEIGAEVPNAETKKAIEDARKGIGMSKAFSSVE
ELMEDLNADD

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D1PSN4

Antitoxin

Source ID Structure

References