253417

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 227390..227955 Replicon chromosome
Accession NZ_CP102293
Organism Subdoligranulum variabile strain DSM 15176

Toxin (Protein)


Gene name relE Uniprot ID D1PML0
Locus tag NQ490_RS01090 Protein ID WP_007046955.1
Coordinates 227390..227680 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag NQ490_RS01095 Protein ID WP_040917696.1
Coordinates 227677..227955 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQ490_RS01055 (NQ490_01055) 222431..223012 - 582 WP_040917689.1 helix-turn-helix transcriptional regulator -
NQ490_RS01060 (NQ490_01060) 223184..223435 + 252 WP_040917692.1 helix-turn-helix transcriptional regulator -
NQ490_RS01065 (NQ490_01065) 223509..224345 + 837 WP_040917694.1 hypothetical protein -
NQ490_RS01075 (NQ490_01075) 225124..225545 - 422 Protein_203 hypothetical protein -
NQ490_RS01080 (NQ490_01080) 225614..226396 - 783 Protein_204 DNA methylase -
NQ490_RS01085 (NQ490_01085) 227127..227324 + 198 WP_007046954.1 helix-turn-helix domain-containing protein -
NQ490_RS01090 (NQ490_01090) 227390..227680 - 291 WP_007046955.1 type II toxin-antitoxin system YafQ family toxin Toxin
NQ490_RS01095 (NQ490_01095) 227677..227955 - 279 WP_040917696.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NQ490_RS01100 (NQ490_01100) 228462..228656 + 195 WP_040918082.1 helix-turn-helix domain-containing protein -
NQ490_RS01105 (NQ490_01105) 228841..230040 + 1200 WP_242654987.1 site-specific integrase -
NQ490_RS01115 (NQ490_01115) 230821..232431 - 1611 WP_007046961.1 potassium/proton antiporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(6-94)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(7-70)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11128.12 Da        Isoelectric Point: 10.0678

>T253417 WP_007046955.1 NZ_CP102293:c227680-227390 [Subdoligranulum variabile]
MSQTKYVVKFTTQFRKDYKLAMKRGLKIELLERIIMLLAAGETLPKKSKDHALTGNWVGHRECHILPDWLLVYRVEDDVL
VLTLTRTGTHSDLFGK

Download         Length: 291 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10140.56 Da        Isoelectric Point: 4.4367

>AT253417 WP_040917696.1 NZ_CP102293:c227955-227677 [Subdoligranulum variabile]
MAGSTTNISIRMDSELKAQADALFAELGMNLSTAFNIFVRQSLREGGIPFEINLNQPNKETIAAMLEAERIAKDPSVKGY
TDVDEMFADLKK

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D1PML0

Antitoxin

Source ID Structure

References