Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-RelB
Location 1427899..1428421 Replicon chromosome
Accession NZ_CP102277
Organism Coprococcus comes ATCC 27758

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag NQ556_RS07020 Protein ID WP_147574863.1
Coordinates 1428158..1428421 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C0B4N5
Locus tag NQ556_RS07015 Protein ID WP_008372201.1
Coordinates 1427899..1428165 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQ556_RS06985 (NQ556_06985) 1422946..1424244 - 1299 WP_022219878.1 nucleotidyltransferase -
NQ556_RS06990 (NQ556_06990) 1424445..1425632 + 1188 WP_008372212.1 acetate kinase -
NQ556_RS06995 (NQ556_06995) 1425730..1426257 + 528 WP_008372210.1 DUF177 domain-containing protein -
NQ556_RS07000 (NQ556_07000) 1426261..1426443 + 183 WP_008372209.1 50S ribosomal protein L32 -
NQ556_RS07005 (NQ556_07005) 1427106..1427345 + 240 WP_008372205.1 helix-turn-helix transcriptional regulator -
NQ556_RS07010 (NQ556_07010) 1427465..1427794 + 330 WP_008372203.1 nucleotidyltransferase domain-containing protein -
NQ556_RS07015 (NQ556_07015) 1427899..1428165 + 267 WP_008372201.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NQ556_RS07020 (NQ556_07020) 1428158..1428421 + 264 WP_147574863.1 Txe/YoeB family addiction module toxin Toxin
NQ556_RS07025 (NQ556_07025) 1428456..1428671 - 216 WP_008372198.1 hypothetical protein -
NQ556_RS07030 (NQ556_07030) 1428951..1429196 + 246 WP_008372194.1 hypothetical protein -
NQ556_RS07035 (NQ556_07035) 1429469..1430536 + 1068 WP_204575905.1 phosphate acyltransferase PlsX -
NQ556_RS07040 (NQ556_07040) 1430558..1430788 + 231 WP_008372189.1 acyl carrier protein -
NQ556_RS07045 (NQ556_07045) 1430856..1431551 + 696 WP_044998976.1 ribonuclease III -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1416373..1580505 164132


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10462.76 Da        Isoelectric Point: 8.7936

>T253411 WP_147574863.1 NZ_CP102277:1428158-1428421 [Coprococcus comes ATCC 27758]
MNKVFTDNGWEDYTYWQTEDKKTLKKINNLIKDIDRNGNEGIGKPEPLTGNLTGFWSRRINDKDRLIYKIDDKNIYILSC
RYHYNDK

Download         Length: 264 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10288.53 Da        Isoelectric Point: 4.2086

>AT253411 WP_008372201.1 NZ_CP102277:1427899-1428165 [Coprococcus comes ATCC 27758]
MLAVNYTNLRDNMKSYMDQVTDDYETMIVTRKNNKNVVMMSEEAYNNLMENVYVMGNKANYDWLMESKAQLEKGNFASHT
LSEVVDDE

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A173STE0

References