Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 1997821..1998371 Replicon chromosome
Accession NZ_CP102270
Organism Butyrivibrio crossotus strain DSM 2876

Toxin (Protein)


Gene name relE Uniprot ID D4RZ62
Locus tag NQ527_RS09805 Protein ID WP_005602462.1
Coordinates 1997821..1998102 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D4RZ63
Locus tag NQ527_RS09810 Protein ID WP_005602465.1
Coordinates 1998102..1998371 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQ527_RS09775 (NQ527_09775) 1993620..1993772 - 153 WP_005602448.1 cyclic lactone autoinducer peptide -
NQ527_RS09780 (NQ527_09780) 1993803..1994414 - 612 WP_005602449.1 accessory gene regulator B family protein -
NQ527_RS09785 (NQ527_09785) 1994469..1995737 - 1269 WP_005602451.1 GHKL domain-containing protein -
NQ527_RS09790 (NQ527_09790) 1995737..1996468 - 732 WP_040331897.1 LytTR family DNA-binding domain-containing protein -
NQ527_RS09795 (NQ527_09795) 1996693..1997298 + 606 WP_005602455.1 abortive infection protein -
NQ527_RS09800 (NQ527_09800) 1997291..1997505 + 215 Protein_1920 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
NQ527_RS09805 (NQ527_09805) 1997821..1998102 - 282 WP_005602462.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
NQ527_RS09810 (NQ527_09810) 1998102..1998371 - 270 WP_005602465.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NQ527_RS09815 (NQ527_09815) 1998555..2000810 - 2256 WP_040331899.1 ABC transporter permease -
NQ527_RS09820 (NQ527_09820) 2000821..2001519 - 699 WP_005602469.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(2-68)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10960.88 Da        Isoelectric Point: 8.0368

>T253408 WP_005602462.1 NZ_CP102270:c1998102-1997821 [Butyrivibrio crossotus]
MQYELILTGKFKKSLKLAKKRGLDLKLLDKVITMLQNDIPLEEKYRDHELKGKYQGFRECHIQPDWLLIYLKENDVLTLT
LVDTGTHADLFNL

Download         Length: 282 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10069.59 Da        Isoelectric Point: 4.6282

>AT253408 WP_005602465.1 NZ_CP102270:c1998371-1998102 [Butyrivibrio crossotus]
MATVPTQVRIDENLKKQASELFSQLGMDMSSAMNIFLKQCVLRGGLPFSVELPQYKPEVLEAMEEAKRISKDPNTKRYAS
FSEALEEID

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D4RZ62

Antitoxin

Source ID Structure
AlphaFold DB D4RZ63

References