Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 876296..876846 Replicon chromosome
Accession NZ_CP102264
Organism Blautia hansenii DSM 20583

Toxin (Protein)


Gene name relE Uniprot ID C9LBU6
Locus tag NQ538_RS04440 Protein ID WP_004223437.1
Coordinates 876565..876846 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID C9LBU7
Locus tag NQ538_RS04435 Protein ID WP_004223440.1
Coordinates 876296..876568 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQ538_RS04415 (NQ538_04415) 871628..873148 + 1521 WP_009246857.1 ABC transporter ATP-binding protein -
NQ538_RS04420 (NQ538_04420) 873150..874238 + 1089 WP_040351279.1 ABC transporter permease -
NQ538_RS04425 (NQ538_04425) 874238..875185 + 948 WP_089438666.1 ABC transporter permease -
NQ538_RS04430 (NQ538_04430) 875194..876153 + 960 WP_004223441.1 biotin--[acetyl-CoA-carboxylase] ligase -
NQ538_RS04435 (NQ538_04435) 876296..876568 + 273 WP_004223440.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NQ538_RS04440 (NQ538_04440) 876565..876846 + 282 WP_004223437.1 type II toxin-antitoxin system YafQ family toxin Toxin
NQ538_RS04445 (NQ538_04445) 876912..877406 - 495 WP_004223436.1 VanZ family protein -
NQ538_RS04450 (NQ538_04450) 877550..878401 + 852 WP_004223433.1 thymidylate synthase -
NQ538_RS04455 (NQ538_04455) 878415..878903 + 489 WP_004223430.1 dihydrofolate reductase -
NQ538_RS04460 (NQ538_04460) 879054..879887 - 834 WP_004223427.1 LarC family nickel insertion protein -
NQ538_RS04465 (NQ538_04465) 879906..880940 - 1035 WP_004223424.1 LacI family DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(6-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-78)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10925.81 Da        Isoelectric Point: 7.2752

>T253399 WP_004223437.1 NZ_CP102264:876565-876846 [Blautia hansenii DSM 20583]
MMYDLILTGKFKKSLKLAKKRGLNISLLEEVVNILQSGEELDKKYRDHELKGKYKNFRECHIQPDWLLIYLIENDILTLT
LVDTGTHADLFNM

Download         Length: 282 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9965.38 Da        Isoelectric Point: 4.5358

>AT253399 WP_004223440.1 NZ_CP102264:876296-876568 [Blautia hansenii DSM 20583]
MKNVTTSIRIDSNTKQAATELLNELGLDLSSAVNIFLKQVVLQGGLPFQVKYPQYKPEVLAAMEEAEALSKNPNTKKYSS
FSEALEDMDI

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C9LBU6

Antitoxin

Source ID Structure
AlphaFold DB C9LBU7

References