Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4724171..4724778 Replicon chromosome
Accession NZ_CP102247
Organism Enterobacter asburiae strain R_A5.MM

Toxin (Protein)


Gene name hicA Uniprot ID A0A7H0N5B9
Locus tag NQ230_RS22430 Protein ID WP_071993467.1
Coordinates 4724593..4724778 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A155E9Y3
Locus tag NQ230_RS22425 Protein ID WP_032675741.1
Coordinates 4724171..4724578 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQ230_RS22405 (NQ230_22405) 4720541..4721194 + 654 WP_257259293.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -
NQ230_RS22410 (NQ230_22410) 4721197..4722057 + 861 WP_257259297.1 L-ribulose-5-phosphate 3-epimerase -
NQ230_RS22415 (NQ230_22415) 4722051..4722746 + 696 WP_257259301.1 L-ribulose-5-phosphate 4-epimerase -
NQ230_RS22420 (NQ230_22420) 4723092..4724167 + 1076 Protein_4369 type I restriction enzyme HsdR N-terminal domain-containing protein -
NQ230_RS22425 (NQ230_22425) 4724171..4724578 - 408 WP_032675741.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NQ230_RS22430 (NQ230_22430) 4724593..4724778 - 186 WP_071993467.1 type II toxin-antitoxin system HicA family toxin Toxin
NQ230_RS22435 (NQ230_22435) 4724988..4725728 - 741 WP_213822179.1 MipA/OmpV family protein -
NQ230_RS22440 (NQ230_22440) 4725846..4726811 + 966 WP_121425999.1 LysR family transcriptional regulator -
NQ230_RS22445 (NQ230_22445) 4726808..4728346 - 1539 WP_029740992.1 aldehyde dehydrogenase AldB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6882.06 Da        Isoelectric Point: 11.2341

>T253397 WP_071993467.1 NZ_CP102247:c4724778-4724593 [Enterobacter asburiae]
VKSADVITVLISHGWKCVRTKGSHHQFRHPEQKGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Download         Length: 186 bp

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 15010.78 Da        Isoelectric Point: 4.3897

>AT253397 WP_032675741.1 NZ_CP102247:c4724578-4724171 [Enterobacter asburiae]
MFYPAYIHSDSDGSASGFFPDVPGCFFAGDSLDDAFQDARDALTAHFEALFEMDNALPLPGNVEAHLESRPEDFTGGQWL
LVDINMKQFDGRAERINITMPRRLLVKIDSFVSEHPQFGNRSAFLAEAARRVLPG

Download         Length: 408 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H0N5B9

Antitoxin

Source ID Structure
AlphaFold DB A0A155E9Y3

References