Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3796461..3797081 Replicon chromosome
Accession NZ_CP102247
Organism Enterobacter asburiae strain R_A5.MM

Toxin (Protein)


Gene name Hha Uniprot ID A0A1H8SI38
Locus tag NQ230_RS18115 Protein ID WP_008499287.1
Coordinates 3796863..3797081 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag NQ230_RS18110 Protein ID WP_008499288.1
Coordinates 3796461..3796835 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQ230_RS18100 (NQ230_18100) 3791588..3792781 + 1194 WP_023310601.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NQ230_RS18105 (NQ230_18105) 3792804..3795950 + 3147 WP_063145542.1 multidrug efflux RND transporter permease subunit AcrB -
NQ230_RS18110 (NQ230_18110) 3796461..3796835 + 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
NQ230_RS18115 (NQ230_18115) 3796863..3797081 + 219 WP_008499287.1 HHA domain-containing protein Toxin
NQ230_RS18120 (NQ230_18120) 3797287..3797838 + 552 WP_159513576.1 maltose O-acetyltransferase -
NQ230_RS18125 (NQ230_18125) 3797956..3798423 + 468 WP_121425576.1 YlaC family protein -
NQ230_RS18130 (NQ230_18130) 3798395..3799855 - 1461 WP_257258529.1 PLP-dependent aminotransferase family protein -
NQ230_RS18135 (NQ230_18135) 3799957..3800667 + 711 WP_257258530.1 GNAT family protein -
NQ230_RS18140 (NQ230_18140) 3800664..3800804 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
NQ230_RS18145 (NQ230_18145) 3800807..3801067 - 261 WP_010428154.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T253395 WP_008499287.1 NZ_CP102247:3796863-3797081 [Enterobacter asburiae]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT253395 WP_008499288.1 NZ_CP102247:3796461-3796835 [Enterobacter asburiae]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8SI38

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References