Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 928246..928903 Replicon chromosome
Accession NZ_CP102247
Organism Enterobacter asburiae strain R_A5.MM

Toxin (Protein)


Gene name cptA Uniprot ID A0A1H8U0Q4
Locus tag NQ230_RS04535 Protein ID WP_021242050.1
Coordinates 928493..928903 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V3PWU7
Locus tag NQ230_RS04530 Protein ID WP_010435322.1
Coordinates 928246..928512 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQ230_RS04510 (NQ230_04510) 923690..925123 - 1434 WP_252033567.1 6-phospho-beta-glucosidase BglA -
NQ230_RS04515 (NQ230_04515) 925240..925971 - 732 WP_121424592.1 MurR/RpiR family transcriptional regulator -
NQ230_RS04520 (NQ230_04520) 926237..926896 + 660 WP_023333307.1 hemolysin III family protein -
NQ230_RS04525 (NQ230_04525) 926971..927951 - 981 WP_121424591.1 tRNA-modifying protein YgfZ -
NQ230_RS04530 (NQ230_04530) 928246..928512 + 267 WP_010435322.1 FAD assembly factor SdhE Antitoxin
NQ230_RS04535 (NQ230_04535) 928493..928903 + 411 WP_021242050.1 protein YgfX Toxin
NQ230_RS04540 (NQ230_04540) 928910..929431 - 522 WP_023333304.1 flavodoxin FldB -
NQ230_RS04545 (NQ230_04545) 929533..930429 + 897 WP_023309098.1 site-specific tyrosine recombinase XerD -
NQ230_RS04550 (NQ230_04550) 930458..931171 + 714 WP_029740340.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NQ230_RS04555 (NQ230_04555) 931177..932910 + 1734 WP_121424590.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16097.08 Da        Isoelectric Point: 10.9468

>T253388 WP_021242050.1 NZ_CP102247:928493-928903 [Enterobacter asburiae]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1340

>AT253388 WP_010435322.1 NZ_CP102247:928246-928512 [Enterobacter asburiae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8U0Q4

Antitoxin

Source ID Structure
AlphaFold DB V3PWU7

References