Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4939630..4940234 Replicon chromosome
Accession NZ_CP102246
Organism Enterobacter cloacae complex sp. R_G8

Toxin (Protein)


Gene name hicA Uniprot ID A0A421IJD5
Locus tag NQ842_RS23295 Protein ID WP_071843252.1
Coordinates 4940049..4940234 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A5E1AFC9
Locus tag NQ842_RS23290 Protein ID WP_023621194.1
Coordinates 4939630..4940034 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQ842_RS23275 (NQ842_23275) 4935165..4935983 - 819 WP_194516699.1 helix-turn-helix domain-containing protein -
NQ842_RS23280 (NQ842_23280) 4936208..4937608 + 1401 WP_063427592.1 MFS transporter -
NQ842_RS23285 (NQ842_23285) 4937619..4939574 + 1956 WP_257256379.1 glycoside hydrolase family 127 protein -
NQ842_RS23290 (NQ842_23290) 4939630..4940034 - 405 WP_023621194.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NQ842_RS23295 (NQ842_23295) 4940049..4940234 - 186 WP_071843252.1 type II toxin-antitoxin system HicA family toxin Toxin
NQ842_RS23300 (NQ842_23300) 4940445..4941185 - 741 WP_063411373.1 MipA/OmpV family protein -
NQ842_RS23305 (NQ842_23305) 4941303..4942269 + 967 Protein_4545 LysR family transcriptional regulator -
NQ842_RS23310 (NQ842_23310) 4942266..4943804 - 1539 WP_257256381.1 aldehyde dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6859.08 Da        Isoelectric Point: 11.7891

>T253387 WP_071843252.1 NZ_CP102246:c4940234-4940049 [Enterobacter cloacae complex sp. R_G8]
VKSADVITVLVRHGWKCVRTKGSHHQFRHPVHAGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Download         Length: 186 bp

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14888.72 Da        Isoelectric Point: 4.3036

>AT253387 WP_023621194.1 NZ_CP102246:c4940034-4939630 [Enterobacter cloacae complex sp. R_G8]
MFYPAYIHSDPDGSASGFFPDVPGCFFAGNSLDDAFQDARDALTAHFEALFEMDEELPLPGNVEAHLEATPGDFIGGQWL
LVDINMKQFDGKAERINITLPRRLLVKIDSFVSEHPQFSNRSAFLAEAARRVLP

Download         Length: 405 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A421IJD5

Antitoxin

Source ID Structure
AlphaFold DB A0A5E1AFC9

References