Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1107670..1108330 Replicon chromosome
Accession NZ_CP102246
Organism Enterobacter cloacae complex sp. R_G8

Toxin (Protein)


Gene name cptA Uniprot ID A0A3R9A2Z6
Locus tag NQ842_RS05305 Protein ID WP_014833181.1
Coordinates 1107917..1108330 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A5E1AG01
Locus tag NQ842_RS05300 Protein ID WP_013098615.1
Coordinates 1107670..1107936 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQ842_RS05280 (NQ842_05280) 1103079..1104512 - 1434 WP_257256595.1 6-phospho-beta-glucosidase -
NQ842_RS05285 (NQ842_05285) 1104629..1105360 - 732 WP_014833183.1 MurR/RpiR family transcriptional regulator -
NQ842_RS05290 (NQ842_05290) 1105626..1106285 + 660 WP_003863433.1 hemolysin III family protein -
NQ842_RS05295 (NQ842_05295) 1106395..1107375 - 981 WP_047361362.1 tRNA-modifying protein YgfZ -
NQ842_RS05300 (NQ842_05300) 1107670..1107936 + 267 WP_013098615.1 FAD assembly factor SdhE Antitoxin
NQ842_RS05305 (NQ842_05305) 1107917..1108330 + 414 WP_014833181.1 protein YgfX Toxin
NQ842_RS05310 (NQ842_05310) 1108337..1108858 - 522 WP_046889569.1 flavodoxin FldB -
NQ842_RS05315 (NQ842_05315) 1108960..1109856 + 897 WP_014833179.1 site-specific tyrosine recombinase XerD -
NQ842_RS05320 (NQ842_05320) 1109885..1110598 + 714 WP_013098611.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NQ842_RS05325 (NQ842_05325) 1110604..1112337 + 1734 WP_257256596.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16206.14 Da        Isoelectric Point: 10.7596

>T253380 WP_014833181.1 NZ_CP102246:1107917-1108330 [Enterobacter cloacae complex sp. R_G8]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGQ
EWDILGMPWMLSSGMMLRLRQVGGGKCQHLWLAADSMDIAEWRDLRRMILQQQPTQE

Download         Length: 414 bp

>T253380 NZ_CP102246:1107917-1108330 [Enterobacter cloacae complex sp. R_G8]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCATGGCGCTCGCAGTGGATGTCGTTATTGCTCCACGGCCTGGTCGCGGC
CTTTGTTTTACTGATGCCGTGGCCGCTTAGCTATACGCCTCTGTGGCTGTTGTTGTTGTCGTTCGTCGTTTTTGACAGCG
TGCGCAGCCAGCGCCGGATCAATGCCCGCCAGGGTGAGATTAAATTACTGATGGACTCCCGCCTGCGCTGGCAGGGGCAG
GAGTGGGATATCCTCGGTATGCCCTGGATGCTCAGTTCCGGCATGATGCTACGGTTACGCCAGGTGGGCGGCGGTAAGTG
CCAGCATCTGTGGCTGGCCGCCGACAGTATGGATATTGCGGAGTGGCGGGATCTGCGCCGGATGATATTGCAGCAGCAAC
CGACGCAGGAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10569.05 Da        Isoelectric Point: 5.1456

>AT253380 WP_013098615.1 NZ_CP102246:1107670-1107936 [Enterobacter cloacae complex sp. R_G8]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDEDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT253380 NZ_CP102246:1107670-1107936 [Enterobacter cloacae complex sp. R_G8]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCATGCCGACGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAATATGAGTATGACAGCTTAAGCGATGAGGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCCGATT
TATTCAACTGGCTGATGAACCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3R9A2Z6

Antitoxin

Source ID Structure
AlphaFold DB A0A5E1AG01

References