Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 238135..238751 Replicon chromosome
Accession NZ_CP102246
Organism Enterobacter cloacae complex sp. R_G8

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NQ842_RS01160 Protein ID WP_080346008.1
Coordinates 238380..238751 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag NQ842_RS01155 Protein ID WP_046889539.1
Coordinates 238135..238377 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQ842_RS01130 (NQ842_01130) 234110..234709 + 600 WP_014833800.1 glucose-1-phosphatase -
NQ842_RS01135 (NQ842_01135) 234703..235584 + 882 WP_014833799.1 virulence factor BrkB family protein -
NQ842_RS01140 (NQ842_01140) 235581..236018 + 438 WP_118284019.1 D-aminoacyl-tRNA deacylase -
NQ842_RS01145 (NQ842_01145) 236063..237004 + 942 WP_013099362.1 fatty acid biosynthesis protein FabY -
NQ842_RS01150 (NQ842_01150) 237017..237934 - 918 WP_257256427.1 alpha/beta hydrolase -
NQ842_RS01155 (NQ842_01155) 238135..238377 + 243 WP_046889539.1 ribbon-helix-helix domain-containing protein Antitoxin
NQ842_RS01160 (NQ842_01160) 238380..238751 + 372 WP_080346008.1 PIN domain-containing protein Toxin
NQ842_RS01165 (NQ842_01165) 238791..239720 - 930 WP_046889538.1 formate dehydrogenase accessory protein FdhE -
NQ842_RS01170 (NQ842_01170) 239717..240352 - 636 WP_014833794.1 formate dehydrogenase cytochrome b556 subunit -
NQ842_RS01175 (NQ842_01175) 240349..241251 - 903 WP_014833793.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13612.75 Da        Isoelectric Point: 6.6407

>T253379 WP_080346008.1 NZ_CP102246:238380-238751 [Enterobacter cloacae complex sp. R_G8]
MTNMAVFDTNILIDLFNNRVEAADAIDHAAAHRAISLITWMEVMVGARRHGHEAKTAAVMGAFEIIDVSRDIAERSVLLR
EKHGMKLPDAIILATAQSRKCPLISRNTKDFAGIDEVVTPYQL

Download         Length: 372 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9413.69 Da        Isoelectric Point: 4.3224

>AT253379 WP_046889539.1 NZ_CP102246:238135-238377 [Enterobacter cloacae complex sp. R_G8]
MSVLAELDMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIELYLDQQSSSVIRDALGLWGDKKEDGLEYERKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References