Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 118029..118654 Replicon plasmid p170Kb
Accession NZ_CP102245
Organism Escherichia coli O7:H15 strain ST70

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NQZ80_RS24575 Protein ID WP_000911317.1
Coordinates 118256..118654 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag NQZ80_RS24570 Protein ID WP_021541611.1
Coordinates 118029..118256 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQZ80_RS24570 (118029) 118029..118256 + 228 WP_021541611.1 toxin-antitoxin system antitoxin VapB Antitoxin
NQZ80_RS24575 (118256) 118256..118654 + 399 WP_000911317.1 type II toxin-antitoxin system VapC family toxin Toxin
NQZ80_RS24580 (118663) 118663..120816 - 2154 WP_021541612.1 type IV conjugative transfer system coupling protein TraD -
NQZ80_RS24585 (121068) 121068..121778 - 711 WP_057729491.1 conjugal transfer complement resistance protein TraT -
NQZ80_RS24590 (121831) 121831..122328 - 498 WP_032149901.1 entry exclusion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - papC / papD / hlyB / iroB / iroC / iroD / iroE / iroN / faeJ / faeI / faeH / faeF / faeE / faeD / faeC 1..170322 170322


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14857.14 Da        Isoelectric Point: 8.5264

>T253375 WP_000911317.1 NZ_CP102245:118256-118654 [Escherichia coli O7:H15]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVGGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8542.58 Da        Isoelectric Point: 4.5358

>AT253375 WP_021541611.1 NZ_CP102245:118029-118256 [Escherichia coli O7:H15]
METTVFLSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGNSVSADFMDNREQPSMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References