Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4571047..4571544 Replicon chromosome
Accession NZ_CP102244
Organism Escherichia coli O7:H15 strain ST70

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag NQZ80_RS21860 Protein ID WP_001173343.1
Coordinates 4571047..4571220 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID A0A2X1N3L1
Locus tag NQZ80_RS21865 Protein ID WP_001560287.1
Coordinates 4571248..4571544 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQZ80_RS21850 (4567717) 4567717..4569174 + 1458 WP_024045128.1 dipeptide/tripeptide permease DtpC -
NQZ80_RS21855 (4569411) 4569411..4570928 + 1518 WP_000003806.1 lysine--tRNA ligase -
NQZ80_RS21860 (4571047) 4571047..4571220 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
NQZ80_RS21865 (4571248) 4571248..4571544 - 297 WP_001560287.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
NQZ80_RS21870 (4571773) 4571773..4572045 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
NQZ80_RS21875 (4572258) 4572258..4576187 - 3930 WP_024046188.1 autotransporter outer membrane beta-barrel domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4571047..4587292 16245


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T253371 WP_001173343.1 NZ_CP102244:c4571220-4571047 [Escherichia coli O7:H15]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11441.94 Da        Isoelectric Point: 4.2924

>AT253371 WP_001560287.1 NZ_CP102244:c4571544-4571248 [Escherichia coli O7:H15]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMHDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB A0A2X1N3L1

References