Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4468989..4469584 Replicon chromosome
Accession NZ_CP102244
Organism Escherichia coli O7:H15 strain ST70

Toxin (Protein)


Gene name chpB Uniprot ID V0SXT4
Locus tag NQZ80_RS21340 Protein ID WP_000239581.1
Coordinates 4468989..4469339 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag NQZ80_RS21345 Protein ID WP_001223213.1
Coordinates 4469333..4469584 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQZ80_RS21320 (4464443) 4464443..4465465 - 1023 WP_001468884.1 ABC transporter permease -
NQZ80_RS21325 (4465479) 4465479..4466981 - 1503 WP_001024741.1 sugar ABC transporter ATP-binding protein -
NQZ80_RS21330 (4467114) 4467114..4468070 - 957 WP_000265935.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
NQZ80_RS21335 (4468380) 4468380..4468910 + 531 WP_000055075.1 inorganic diphosphatase -
NQZ80_RS21340 (4468989) 4468989..4469339 - 351 WP_000239581.1 endoribonuclease toxin ChpB Toxin
NQZ80_RS21345 (4469333) 4469333..4469584 - 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
NQZ80_RS21350 (4469796) 4469796..4470137 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
NQZ80_RS21355 (4470140) 4470140..4473919 - 3780 WP_000060909.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12453.41 Da        Isoelectric Point: 6.2206

>T253370 WP_000239581.1 NZ_CP102244:c4469339-4468989 [Escherichia coli O7:H15]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT253370 WP_001223213.1 NZ_CP102244:c4469584-4469333 [Escherichia coli O7:H15]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SXT4

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References