Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4457448..4457970 Replicon chromosome
Accession NZ_CP102244
Organism Escherichia coli O7:H15 strain ST70

Toxin (Protein)


Gene name relE Uniprot ID A0A829L6G8
Locus tag NQZ80_RS21280 Protein ID WP_001105433.1
Coordinates 4457448..4457738 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SC69
Locus tag NQZ80_RS21285 Protein ID WP_000212715.1
Coordinates 4457728..4457970 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQZ80_RS21265 (4452638) 4452638..4454293 + 1656 WP_024216595.1 alpha,alpha-phosphotrehalase -
NQZ80_RS21270 (4454687) 4454687..4456825 + 2139 WP_000187799.1 anaerobic ribonucleoside-triphosphate reductase -
NQZ80_RS21275 (4456983) 4456983..4457447 + 465 WP_001106233.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NQZ80_RS21280 (4457448) 4457448..4457738 - 291 WP_001105433.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NQZ80_RS21285 (4457728) 4457728..4457970 - 243 WP_000212715.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NQZ80_RS21290 (4458162) 4458162..4458548 - 387 WP_001232246.1 cytochrome b562 -
NQZ80_RS21295 (4458732) 4458732..4460084 - 1353 WP_033560718.1 metalloprotease PmbA -
NQZ80_RS21300 (4460178) 4460178..4460729 + 552 WP_000166295.1 ribosome biogenesis factor YjgA -
NQZ80_RS21305 (4460881) 4460881..4462254 - 1374 WP_001219792.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11367.23 Da        Isoelectric Point: 10.0238

>T253369 WP_001105433.1 NZ_CP102244:c4457738-4457448 [Escherichia coli O7:H15]
MNYELAFDPRALKEWQKLGVTVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTQGYRLVYQVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9125.56 Da        Isoelectric Point: 5.1369

>AT253369 WP_000212715.1 NZ_CP102244:c4457970-4457728 [Escherichia coli O7:H15]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829L6G8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H4B3

References