Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2675684..2676322 Replicon chromosome
Accession NZ_CP102244
Organism Escherichia coli O7:H15 strain ST70

Toxin (Protein)


Gene name hicA Uniprot ID A0A7U9DHD1
Locus tag NQZ80_RS12880 Protein ID WP_000813795.1
Coordinates 2676146..2676322 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NQZ80_RS12875 Protein ID WP_001270286.1
Coordinates 2675684..2676100 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQZ80_RS12855 (2670836) 2670836..2671777 - 942 WP_024216494.1 ABC transporter permease -
NQZ80_RS12860 (2671778) 2671778..2672791 - 1014 WP_024042137.1 ABC transporter ATP-binding protein -
NQZ80_RS12865 (2672809) 2672809..2673954 - 1146 WP_024042138.1 ABC transporter substrate-binding protein -
NQZ80_RS12870 (2674199) 2674199..2675605 - 1407 WP_024042139.1 PLP-dependent aminotransferase family protein -
NQZ80_RS12875 (2675684) 2675684..2676100 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
NQZ80_RS12880 (2676146) 2676146..2676322 - 177 WP_000813795.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
NQZ80_RS12885 (2676544) 2676544..2676774 + 231 WP_000494244.1 YncJ family protein -
NQZ80_RS12890 (2676866) 2676866..2678827 - 1962 WP_024216495.1 23S rRNA 5-hydroxycytidine C2501 synthase -
NQZ80_RS12895 (2678900) 2678900..2679436 - 537 WP_024044350.1 DNA-binding transcriptional regulator SutR -
NQZ80_RS12900 (2679528) 2679528..2680700 + 1173 WP_024044351.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6747.80 Da        Isoelectric Point: 11.5666

>T253364 WP_000813795.1 NZ_CP102244:c2676322-2676146 [Escherichia coli O7:H15]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPSEEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT253364 WP_001270286.1 NZ_CP102244:c2676100-2675684 [Escherichia coli O7:H15]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9DHD1

Antitoxin

Source ID Structure

References