Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2576853..2578441 Replicon chromosome
Accession NZ_CP102244
Organism Escherichia coli O7:H15 strain ST70

Toxin (Protein)


Gene name hipA Uniprot ID U9YVT8
Locus tag NQZ80_RS12465 Protein ID WP_001125415.1
Coordinates 2577119..2578441 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A366Y5V8
Locus tag NQZ80_RS12460 Protein ID WP_001366357.1
Coordinates 2576853..2577119 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQZ80_RS12460 (2576853) 2576853..2577119 + 267 WP_001366357.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NQZ80_RS12465 (2577119) 2577119..2578441 + 1323 WP_001125415.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
NQZ80_RS12470 (2578839) 2578839..2579738 - 900 WP_024216268.1 LysR family transcriptional regulator -
NQZ80_RS12475 (2579878) 2579878..2580186 + 309 WP_024044634.1 hypothetical protein -
NQZ80_RS12480 (2580195) 2580195..2580884 + 690 WP_000801313.1 type 1 glutamine amidotransferase domain-containing protein -
NQZ80_RS12485 (2580958) 2580958..2581905 + 948 WP_000854796.1 aldo/keto reductase -
NQZ80_RS12490 (2582008) 2582008..2582163 + 156 WP_001322415.1 hypothetical protein -
NQZ80_RS12495 (2582123) 2582123..2582686 + 564 WP_077688251.1 amidohydrolase family protein -
NQZ80_RS12500 (2582837) 2582837..2583409 + 573 WP_024044636.1 NAD(P)H-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49384.05 Da        Isoelectric Point: 8.5830

>T253363 WP_001125415.1 NZ_CP102244:2577119-2578441 [Escherichia coli O7:H15]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLANRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHRRLSREYGIK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10077.48 Da        Isoelectric Point: 4.9632

>AT253363 WP_001366357.1 NZ_CP102244:2576853-2577119 [Escherichia coli O7:H15]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLMTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YVT8

Antitoxin

Source ID Structure
AlphaFold DB A0A366Y5V8

References