Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 970007..970661 Replicon chromosome
Accession NZ_CP102244
Organism Escherichia coli O7:H15 strain ST70

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag NQZ80_RS04710 Protein ID WP_000244781.1
Coordinates 970254..970661 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag NQZ80_RS04705 Protein ID WP_000354046.1
Coordinates 970007..970273 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQZ80_RS04685 (966095) 966095..967528 - 1434 WP_001305827.1 6-phospho-beta-glucosidase BglA -
NQZ80_RS04690 (967573) 967573..967884 + 312 WP_001182966.1 N(4)-acetylcytidine aminohydrolase -
NQZ80_RS04695 (968048) 968048..968707 + 660 WP_000250274.1 hemolysin III family protein -
NQZ80_RS04700 (968784) 968784..969764 - 981 WP_000886051.1 tRNA-modifying protein YgfZ -
NQZ80_RS04705 (970007) 970007..970273 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
NQZ80_RS04710 (970254) 970254..970661 + 408 WP_000244781.1 protein YgfX Toxin
NQZ80_RS04715 (970701) 970701..971222 - 522 WP_001055888.1 flavodoxin FldB -
NQZ80_RS04720 (971334) 971334..972230 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
NQZ80_RS04725 (972255) 972255..972965 + 711 WP_000715213.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NQZ80_RS04730 (972971) 972971..974704 + 1734 WP_000813175.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T253356 WP_000244781.1 NZ_CP102244:970254-970661 [Escherichia coli O7:H15]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT253356 WP_000354046.1 NZ_CP102244:970007-970273 [Escherichia coli O7:H15]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References